Outcome of Pregnancy with Hemoglobinopathy in a Tertiary Care Center

Overview

Journal J Obstet Gynaecol India

Specialty Gynecology & Obstetrics

Date 2018 Sep 19

PMID 30224845

Citations 1

Authors

Anahita Chauhan

Madhva Prasad

Affiliations

Soon will be listed here.

Abstract

Purpose: The objective was to observe the characteristics among pregnant patients with a diagnosed hemoglobinopathy and to study the obstetric and medical morbidity patterns during the antenatal and the perinatal periods in this group of patients.

Methods: A prospective observational study was conducted in a tertiary care center.

Results: Sixty patients were studied in 11 months. Primigravidae (43.3%) formed the highest percentage of patients. β Thalassemia trait was the most common hemoglobinopathy, seen in 81.66% of study subjects. The hemoglobin value ranged from 5.7 to 13.0, with an average of 9.2 g/dl. Thyroid problems were the most common associated medical disorder. Though IUGR and placenta previa were common, there were no major obstetric problems. There were 57 live births and 1 fresh stillbirth. Two patients had spontaneous abortion for which uterine curettage was done. LSCS was the most common obstetric outcome. Patients with sickle-cell disease required more blood transfusion than those with beta-thalassemia trait. There were 2 maternal mortalities, and both the patients were the diagnosed cases of sickle-cell disease.

Conclusions: While the perinatal outcomes among women with sickle-cell disease are poor, the outcomes in pregnant patients with beta-thalassemia trait were not a cause of major concern.

Citing Articles

New Entity-Thalassemic Endocrine Disease: Major Beta-Thalassemia and Endocrine Involvement.

Carsote M, Vasiliu C, Trandafir A, Albu S, Dumitrascu M, Popa A Diagnostics (Basel). 2022; 12(8).

PMID: 36010271 PMC: 9406368. DOI: 10.3390/diagnostics12081921.

References

Cassinerio E, Baldini I, Alameddine R, Marcon A, Borroni R, Ossola W . Pregnancy in patients with thalassemia major: a cohort study and conclusions for an adequate care management approach. Ann Hematol. 2017; 96(6):1015-1021. DOI: 10.1007/s00277-017-2979-9. View

Desai G, Anand A, Shah P, Shah S, Dave K, Bhatt H . Sickle cell disease and pregnancy outcomes: a study of the community-based hospital in a tribal block of Gujarat, India. J Health Popul Nutr. 2017; 36(1):3. PMC: 5251338. DOI: 10.1186/s41043-017-0079-z. View

Baxi A, Manila K, Kadhi P, Heena B . Carrier Screening for β Thalassemia in Pregnant Indian Women: Experience at a Single Center in Madhya Pradesh. Indian J Hematol Blood Transfus. 2014; 29(2):71-4. PMC: 3636359. DOI: 10.1007/s12288-012-0165-8. View

Mondal S, Mandal S . Prevalence of thalassemia and hemoglobinopathy in eastern India: A 10-year high-performance liquid chromatography study of 119,336 cases. Asian J Transfus Sci. 2016; 10(1):105-10. PMC: 4782486. DOI: 10.4103/0973-6247.175424. View

Hanprasertpong T, Kor-Anantakul O, Leetanaporn R, Suntharasaj T, Suwanrath C, Pruksanusak N . Pregnancy outcomes amongst thalassemia traits. Arch Gynecol Obstet. 2013; 288(5):1051-4. PMC: 3824192. DOI: 10.1007/s00404-013-2886-9. View

Colah R, Gorakshakar A, Phanasgaonkar S, DSouza E, Nadkarni A, Surve R . Epidemiology of beta-thalassaemia in Western India: mapping the frequencies and mutations in sub-regions of Maharashtra and Gujarat. Br J Haematol. 2010; 149(5):739-47. DOI: 10.1111/j.1365-2141.2010.08131.x. View

Vuthiwong C, Panichkul P, Punpuckdeekoon P . Causes and attitude of husbands toward thalassemic carrier screening test when their partners have abnormal screening tests. J Med Assoc Thai. 2012; 95 Suppl 5:S162-7. View

Tsatalas C, Chalkia P, Pantelidou D, Margaritis D, Bourikas G, Spanoudakis E . Pregnancy in beta-thalassemia trait carriers: an uneventful journey. Hematology. 2009; 14(5):301-3. DOI: 10.1179/102453309X439791. View

Asnafi N, Niaki H . Pregnancy outcome of chorionic villus sampling on 260 couples with beta-thalassemia trait in north of Iran. Acta Med Iran. 2010; 48(3):168-71. View

10.

El-Beshlawy A, El-Shekha A, Momtaz M, Said F, Hamdy M, Osman O . Prenatal diagnosis for thalassaemia in Egypt: what changed parents' attitude?. Prenat Diagn. 2012; 32(8):777-82. DOI: 10.1002/pd.3901. View

11.

Dolai T, Dutta S, Bhattacharyya M, Kumar Ghosh M . Prevalence of hemoglobinopathies in rural Bengal, India. Hemoglobin. 2011; 36(1):57-63. DOI: 10.3109/03630269.2011.621007. View

12.

Muganyizi P, Kidanto H . Sickle cell disease in pregnancy: trend and pregnancy outcomes at a tertiary hospital in Tanzania. PLoS One. 2013; 8(2):e56541. PMC: 3572068. DOI: 10.1371/journal.pone.0056541. View

13.

Nassar A, Naja M, Cesaretti C, Eprassi B, Cappellini M, Taher A . Pregnancy outcome in patients with beta-thalassemia intermedia at two tertiary care centers, in Beirut and Milan. Haematologica. 2008; 93(10):1586-7. DOI: 10.3324/haematol.13152. View

14.

Rogers D, Molokie R . Sickle cell disease in pregnancy. Obstet Gynecol Clin North Am. 2010; 37(2):223-37. DOI: 10.1016/j.ogc.2010.02.015. View

15.

Charoenboon C, Jatavan P, Traisrisilp K, Tongsong T . Pregnancy outcomes among women with beta-thalassemia trait. Arch Gynecol Obstet. 2015; 293(4):771-4. DOI: 10.1007/s00404-015-3908-6. View

16.

Daigavane M, Jena R, Kar T . Perinatal outcome in sickle cell anemia: a prospective study from India. Hemoglobin. 2013; 37(6):507-15. DOI: 10.3109/03630269.2013.828301. View

17.

Yordanova D, Nikolov A, Museva A, Karamiseva V . [The pregnancy outcome in patients WITH β-thalassemia minor]. Akush Ginekol (Sofiia). 2014; 53 Suppl 1:20-4. View

18.

Kemthong W, Jatavan P, Traisrisilp K, Tongsong T . Pregnancy outcomes among women with hemoglobin E trait. J Matern Fetal Neonatal Med. 2015; 29(7):1146-8. DOI: 10.3109/14767058.2015.1038515. View

19.

Voskaridou E, Balassopoulou A, Boutou E, Komninaka V, Christoulas D, Dimopoulou M . Pregnancy in beta-thalassemia intermedia: 20-year experience of a Greek thalassemia center. Eur J Haematol. 2014; 93(6):492-9. DOI: 10.1111/ejh.12387. View