Vitamin D Status in Mothers and Their Newborns and Its Association with Pregnancy Outcomes: Experience from a Tertiary Care Center in Northern India

Overview

Journal J Obstet Gynaecol India

Specialty Gynecology & Obstetrics

Date 2018 Sep 19

PMID 30224844

Citations 13

Authors

Saloni Arora

Poonam Goel

Deepak Chawla

Anju Huria

Adhi Arya

Affiliations

Soon will be listed here.

Abstract

Objective: Study was planned to know vitamin D status in mothers and their newborns and effect of vitamin D deficiency on pregnancy outcome. Study design: Two hundred consecutive pregnant women with singleton pregnancy admitted to the labor ward of a tertiary care center were recruited for the study. Maternal and cord blood samples were taken and analyzed for 25(OH) D level. Maternal and fetal outcomes were studied.

Results: High prevalence of hypovitaminosis D was found among pregnant women. Eighty-six percentage had vitamin D deficiency, 9.5% had insufficiency, and only 4.5% had sufficient vitamin D level. Women with preeclampsia had statistically significant vitamin D deficiency and insufficiency as compared to patients who had normal blood pressure levels ( = 0.04). Cesarean section rate was significantly higher in patients with vitamin D deficiency and insufficiency compared to sufficient group ( = 0.004). Cord blood 25(OH) D levels strongly correlated with maternal serum 25 (OH) D levels ( = 0.001, correlation coefficient = 0.84).

Conclusions: This study showed a very high prevalence of hypovitaminosis D among pregnant women and excellent correlation between maternal and fetal 25(OH) D levels. Hypovitaminosis D was associated with preeclampsia, increased Cesarean rate, and low birth weight babies.

Citing Articles

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References

Sahu M, Bhatia V, Aggarwal A, Rawat V, Saxena P, Pandey A . Vitamin D deficiency in rural girls and pregnant women despite abundant sunshine in northern India. Clin Endocrinol (Oxf). 2008; 70(5):680-4. DOI: 10.1111/j.1365-2265.2008.03360.x. View

Merewood A, Mehta S, Chen T, Bauchner H, Holick M . Association between vitamin D deficiency and primary cesarean section. J Clin Endocrinol Metab. 2008; 94(3):940-5. PMC: 2681281. DOI: 10.1210/jc.2008-1217. View

Sabour H, Hossein-Nezhad A, Maghbooli Z, Madani F, Mir E, Larijani B . Relationship between pregnancy outcomes and maternal vitamin D and calcium intake: A cross-sectional study. Gynecol Endocrinol. 2006; 22(10):585-9. DOI: 10.1080/09513590601005409. View

Amirlak I, Ezimokhai M, Dawodu A, Dawson K, Kochiyil J, Thomas L . Current maternal-infant micronutrient status and the effects on birth weight in the United Arab Emirates. East Mediterr Health J. 2010; 15(6):1399-406. View

Baker A, Haeri S, Camargo Jr C, Espinola J, Stuebe A . A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab. 2010; 95(11):5105-9. PMC: 2968727. DOI: 10.1210/jc.2010-0996. View

Bowyer L, Catling-Paull C, Diamond T, Homer C, Davis G, Craig M . Vitamin D, PTH and calcium levels in pregnant women and their neonates. Clin Endocrinol (Oxf). 2008; 70(3):372-7. DOI: 10.1111/j.1365-2265.2008.03316.x. View

Lips P . Vitamin D physiology. Prog Biophys Mol Biol. 2006; 92(1):4-8. DOI: 10.1016/j.pbiomolbio.2006.02.016. View

Bodnar L, Catov J, Simhan H, Holick M, Powers R, Roberts J . Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab. 2007; 92(9):3517-22. PMC: 4288954. DOI: 10.1210/jc.2007-0718. View

Sachan A, Gupta R, Das V, Agarwal A, Awasthi P, Bhatia V . High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India. Am J Clin Nutr. 2005; 81(5):1060-4. DOI: 10.1093/ajcn/81.5.1060. View

10.

Marwaha R, Tandon N, Chopra S, Agarwal N, Garg M, Sharma B . Vitamin D status in pregnant Indian women across trimesters and different seasons and its correlation with neonatal serum 25-hydroxyvitamin D levels. Br J Nutr. 2011; 106(9):1383-9. DOI: 10.1017/S000711451100170X. View

11.

Robinson C, Alanis M, Wagner C, Hollis B, Johnson D . Plasma 25-hydroxyvitamin D levels in early-onset severe preeclampsia. Am J Obstet Gynecol. 2010; 203(4):366.e1-6. PMC: 3192365. DOI: 10.1016/j.ajog.2010.06.036. View

12.

Farrant H, Krishnaveni G, Hill J, Boucher B, Fisher D, Noonan K . Vitamin D insufficiency is common in Indian mothers but is not associated with gestational diabetes or variation in newborn size. Eur J Clin Nutr. 2008; 63(5):646-52. PMC: 2678985. DOI: 10.1038/ejcn.2008.14. View

13.

Fernandez-Alonso A, Dionis-Sanchez E, Chedraui P, Gonzalez-Salmeron M, Perez-Lopez F . First-trimester maternal serum 25-hydroxyvitamin D₃ status and pregnancy outcome. Int J Gynaecol Obstet. 2011; 116(1):6-9. DOI: 10.1016/j.ijgo.2011.07.029. View

14.

Leffelaar E, Vrijkotte T, van Eijsden M . Maternal early pregnancy vitamin D status in relation to fetal and neonatal growth: results of the multi-ethnic Amsterdam Born Children and their Development cohort. Br J Nutr. 2010; 104(1):108-17. DOI: 10.1017/S000711451000022X. View

15.

Agarwal N, Arya S . Vitamin D₃ levels in pregnant women and newborns at a private tertiary care hospital in Delhi, India. Int J Gynaecol Obstet. 2011; 113(3):240-1. DOI: 10.1016/j.ijgo.2011.01.005. View

16.

Maghbooli Z, Hossein-Nezhad A, Shafaei A, Karimi F, Madani F, Larijani B . Vitamin D status in mothers and their newborns in Iran. BMC Pregnancy Childbirth. 2007; 7:1. PMC: 1808477. DOI: 10.1186/1471-2393-7-1. View

17.

Jain V, Gupta N, Kalaivani M, Jain A, Sinha A, Agarwal R . Vitamin D deficiency in healthy breastfed term infants at 3 months & their mothers in India: seasonal variation & determinants. Indian J Med Res. 2011; 133:267-73. PMC: 3103150. View

18.

. ACOG Committee Opinion No. 495: Vitamin D: Screening and supplementation during pregnancy. Obstet Gynecol. 2011; 118(1):197-198. DOI: 10.1097/AOG.0b013e318227f06b. View