Salivary Antibodies As a Means of Detecting Human T Cell Lymphotropic Virus Type III/lymphadenopathy-associated Virus Infection

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1986 Nov 1

PMID 3021816

Citations 11

Authors

D W ARCHIBALD

L I Zon

J E Groopman

J S Allan

M F McLane

M E Essex

Affiliations

Soon will be listed here.

Abstract

Of 45 individuals seropositive for human T cell lymphotropic virus type III/lymphadenopathy-associated virus, 45 were found to have detectable salivary antibodies to viral antigens by a radioimmunoprecipitation assay. The results also showed that a Western blot assay for salivary antibodies may be possible. The feasibility of a diagnostic test for human T cell lymphotropic virus type III/lymphadenopathy-associated virus not requiring venipuncture is discussed.

Citing Articles

Salivary biomarkers in COVID-19 patients.

Ubhale R, Dahake S, Madhu P, Gaurav Chhabra K, Reche A, Bankar A J Family Med Prim Care. 2023; 11(11):6778-6782.

PMID: 36992999 PMC: 10041187. DOI: 10.4103/jfmpc.jfmpc_1569_21.

Saliva and viral infections.

Corstjens P, Abrams W, Malamud D Periodontol 2000. 2015; 70(1):93-110.

PMID: 26662485 PMC: 7167623. DOI: 10.1111/prd.12112.

Importance of collection methods and stability of oral fluid samples for hepatitis B surface antigen detection.

Scalioni L, Cruz H, de Paula V, Correia Oliveira J, Tourinho Dos Santos R, Coimbra Motta-Castro A J Clin Lab Anal. 2013; 27(3):186-94.

PMID: 23440736 PMC: 6807626. DOI: 10.1002/jcla.21582.

Detecting viruses by using salivary diagnostics.

Corstjens P, Abrams W, Malamud D J Am Dent Assoc. 2012; 143(10 Suppl):12S-8S.

PMID: 23034833 PMC: 4262792. DOI: 10.14219/jada.archive.2012.0338.

Detection of human immunodeficiency virus antibodies in oral fluids.

Hodinka R, Nagashunmugam T, Malamud D Clin Diagn Lab Immunol. 1998; 5(4):419-26.

PMID: 9665942 PMC: 95593. DOI: 10.1128/CDLI.5.4.419-426.1998.

References

PERKINS J, TUCKER D, Knope H, Wenzel R, Hornick R, Kapikian A . Evidence for protective effect of an inactivated rhinovirus vaccine administered by the nasal route. Am J Epidemiol. 1969; 90(4):319-26. DOI: 10.1093/oxfordjournals.aje.a121076. View

ARCHIBALD D, Zon L, Groopman J, McLane M, Essex M . Antibodies to human T-lymphotropic virus type III (HTLV-III) in saliva of acquired immunodeficiency syndrome (AIDS) patients and in persons at risk for AIDS. Blood. 1986; 67(3):831-4. View

Towbin H, Staehelin T, Gordon J . Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979; 76(9):4350-4. PMC: 411572. DOI: 10.1073/pnas.76.9.4350. View

Fauci A . The acquired immune deficiency syndrome. The ever-broadening clinical spectrum. JAMA. 1983; 249(17):2375-6. View

Essex M, McLane M, Lee T, Falk L, HOWE C, Mullins J . Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS. Science. 1983; 220(4599):859-62. DOI: 10.1126/science.6342136. View

Barre-Sinoussi F, Chermann J, Rey F, Nugeyre M, Chamaret S, Gruest J . Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science. 1983; 220(4599):868-71. DOI: 10.1126/science.6189183. View

Fauci A, Macher A, Longo D, Lane H, Rook A, Masur H . NIH conference. Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann Intern Med. 1984; 100(1):92-106. DOI: 10.7326/0003-4819-100-1-92. View

Popovic M, Sarngadharan M, Read E, Gallo R . Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science. 1984; 224(4648):497-500. DOI: 10.1126/science.6200935. View

Gallo R, Salahuddin S, Popovic M, Shearer G, Kaplan M, Haynes B . Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science. 1984; 224(4648):500-3. DOI: 10.1126/science.6200936. View

10.

Sarngadharan M, Popovic M, Bruch L, Schupbach J, Gallo R . Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science. 1984; 224(4648):506-8. DOI: 10.1126/science.6324345. View

11.

Groopman J, Salahuddin S, Sarngadharan M, Markham P, Gonda M, Sliski A . HTLV-III in saliva of people with AIDS-related complex and healthy homosexual men at risk for AIDS. Science. 1984; 226(4673):447-9. DOI: 10.1126/science.6093247. View

12.

Kitchen L, Barin F, Sullivan J, McLane M, Brettler D, Levine P . Aetiology of AIDS--antibodies to human T-cell leukaemia virus (type III) in haemophiliacs. Nature. 1984; 312(5992):367-9. DOI: 10.1038/312367a0. View

13.

Shaw G, Broder S, Essex M, Gallo R . Human T-cell leukemia virus: its discovery and role in leukemogenesis and immunosuppression. Adv Intern Med. 1984; 30:1-27. View

14.

Allan J, Coligan J, Barin F, McLane M, Sodroski J, Rosen C . Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III. Science. 1985; 228(4703):1091-4. DOI: 10.1126/science.2986290. View

15.

Barin F, McLane M, Allan J, Lee T, Groopman J, Essex M . Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients. Science. 1985; 228(4703):1094-6. DOI: 10.1126/science.2986291. View

16.

Ho D, Byington R, Schooley R, Flynn T, ROTA T, Hirsch M . Infrequency of isolation of HTLV-III virus from saliva in AIDS. N Engl J Med. 1985; 313(25):1606. DOI: 10.1056/NEJM198512193132512. View

17.

Barin F, Mboup S, Denis F, Kanki P, Allan J, Lee T . Serological evidence for virus related to simian T-lymphotropic retrovirus III in residents of west Africa. Lancet. 1985; 2(8469-70):1387-9. DOI: 10.1016/s0140-6736(85)92556-5. View

18.

Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View