Evidence for Evolutionary Duplication of Genes in the Dopa Decarboxylase Region of Drosophila

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 1986 Oct 1

PMID 3021572

Citations 11

Authors

D D Eveleth

J L Marsh

Affiliations

Soon will be listed here.

Abstract

The region surrounding the dopa decarboxylase gene (Ddc) of Drosophila contains a cluster of genes, many of which appear to be functionally related by virtue of their effects on cuticle development and/or catecholamine metabolism. In this report we describe evidence that the Ddc gene and the closely linked alpha-methyldopa hypersensitive (amd) gene share extensive sequence homology and are the products of a gene duplication event. The two genes are transcribed convergently and are separated by 2.4 kb. A gene located between Ddc and amd expresses a 2.0-kb mRNA and appears to partially overlap the Ddc gene. The organization of these transcripts implies a complex series of events giving rise to the present pattern. The patterns of expression of these genes do not support a model of coordinate regulation, but are more consistent with a pattern of duplication and divergence to various related metabolic subspecialties. These data provide the first evidence for structural relationships among genes in the 37C cluster.

Citing Articles

The catecholamines up (Catsup) protein of Drosophila melanogaster functions as a negative regulator of tyrosine hydroxylase activity.

Stathakis D, Burton D, McIvor W, Krishnakumar S, Wright T, ODonnell J Genetics. 1999; 153(1):361-82.

PMID: 10471719 PMC: 1460756. DOI: 10.1093/genetics/153.1.361.

Molecular characterization of neurally expressing genes in the para sodium channel gene cluster of drosophila.

Hong C, Ganetzky B Genetics. 1996; 142(3):879-92.

PMID: 8849894 PMC: 1207025. DOI: 10.1093/genetics/142.3.879.

Evolutionary changes in the expression pattern of a developmentally essential gene in three Drosophila species.

Wang D, Marsh J, Ayala F Proc Natl Acad Sci U S A. 1996; 93(14):7103-7.

PMID: 8692952 PMC: 38943. DOI: 10.1073/pnas.93.14.7103.

Overlapping transcription units in Drosophila: sequence and structure of the Cs gene.

Eveleth D, Marsh J Mol Gen Genet. 1987; 209(2):290-8.

PMID: 3478553 DOI: 10.1007/BF00329656.

The alpha methyl dopa hypersensitive gene, 1(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism.

Black B, Pentz E, Wright T Mol Gen Genet. 1987; 209(2):306-12.

PMID: 3118145 DOI: 10.1007/BF00329658.

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