Intratumoral Hemorrhage of Liver Metastasis from a Rectal Neuroendocrine Tumor

Overview

Journal Intern Med

Specialty General Medicine

Date 2018 Sep 14

PMID 30210114

Authors

Takeshi Hatanaka

Atsushi Naganuma

Takahiro Saito

Takashi Hoshino

Satoru Kakizaki

Toshio Kumasaka

Takeshi Takamoto

Masatoshi Makuuchi

Affiliations

Soon will be listed here.

Abstract

A 56-year-old healthy woman was referred to our hospital for abdominal pain. Contrast-enhanced computed tomography (CT) showed a 14-cm-diameter liver tumor with intratumoral hemorrhage. We performed emergent transcatheter arterial embolization. She was referred to hepatic surgeon (M.M.) for resection. Preoperative colonoscopy showed an elevated lesion measuring 2 cm in diameter that was pathologically diagnosed as a rectal neuroendocrine tumor (NET). We performed low anterior resection of the rectum, followed by extended right hepatectomy for all hepatic lesions. Intratumoral hematoma was observed in the largest hepatic lesion (size: 150 mm×100 mm). Microscopy also indicated NET G2. We pathologically diagnosed a liver tumor from a rectal NET that bled spontaneously.

References

Tsutani H, Inai K, Kishi S, Morinaga K, Naiki H, Ueda T . Hepatic tumor rupture following effectual treatment with irinotecan in a patient with highly refractory malignant lymphoma. Int J Hematol. 1999; 70(3):178-80. View

La Fianza A, Alberici E, Biasina A, Preda L, Tateo S, Campani R . Spontaneous hemorrhage of a liver metastasis from squamous cell cervical carcinoma: case report and review of the literature. Tumori. 1999; 85(4):290-3. DOI: 10.1177/030089169908500416. View

Casillas V, Amendola M, Gascue A, Pinnar N, Levi J, Perez J . Imaging of nontraumatic hemorrhagic hepatic lesions. Radiographics. 2000; 20(2):367-78. DOI: 10.1148/radiographics.20.2.g00mc10367. View

Murakami R, Taniai N, Kumazaki T, Kobayashi Y, Ogura J, Ichikawa T . Rupture of a hepatic metastasis from renal cell carcinoma. Clin Imaging. 2000; 24(2):72-4. DOI: 10.1016/s0899-7071(00)00173-x. View

Tung C, Chang C, Chow W, Peng Y, Hwang J, Wen M . Hemoperitoneum secondary to spontaneous rupture of metastatic epidermoid carcinoma of liver: case report and review of the literature. Hepatogastroenterology. 2002; 49(47):1415-7. View

Chen Z, Qi Q, Dong Z . Etiology and management of hemmorrhage in spontaneous liver rupture: a report of 70 cases. World J Gastroenterol. 2002; 8(6):1063-6. PMC: 4656381. DOI: 10.3748/wjg.v8.i6.1063. View

Sakai M, Oguri T, Sato S, Hattori N, Bessho Y, Achiwa H . Spontaneous hepatic rupture due to metastatic tumor of lung adenocarcinoma. Intern Med. 2005; 44(1):50-4. DOI: 10.2169/internalmedicine.44.50. View

Kadowaki T, Hamada H, Yokoyama A, Ito R, Ishimaru S, Ohnishi H . Hemoperitoneum secondary to spontaneous rupture of hepatic metastasis from lung cancer. Intern Med. 2005; 44(4):290-3. DOI: 10.2169/internalmedicine.44.290. View

Lai E, Lau W . Spontaneous rupture of hepatocellular carcinoma: a systematic review. Arch Surg. 2006; 141(2):191-8. DOI: 10.1001/archsurg.141.2.191. View

10.

Hess K, Varadhachary G, Taylor S, Wei W, Raber M, Lenzi R . Metastatic patterns in adenocarcinoma. Cancer. 2006; 106(7):1624-33. DOI: 10.1002/cncr.21778. View

11.

Schoedel K, Dekker A . Hemoperitoneum in the setting of metastatic cancer to the liver. A report of two cases with review of the literature. Dig Dis Sci. 1992; 37(1):153-4. DOI: 10.1007/BF01308360. View

12.

Welch M . Spontaneous hepatic rupture due to metastatic malignant melanoma. Postgrad Med J. 1991; 67(793):1028-9. PMC: 2399125. DOI: 10.1136/pgmj.67.793.1028-a. View

13.

Yao J, Hassan M, Phan A, Dagohoy C, Leary C, Mares J . One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 2008; 26(18):3063-72. DOI: 10.1200/JCO.2007.15.4377. View

14.

Dewar G, Griffin S, van Hasselt C, Lam W, Li A . Fatal haemoperitoneum as a result of liver metastases from nasopharyngeal cancer. Eur J Surg Oncol. 1991; 17(5):551-4. View

15.

Dousei T, Miyata M, Yamaguchi T, Nagaoka M, Takahashi E, Kawashima Y . Rupture of liver metastasis of malignant melanoma--a case of hepatic resection. Jpn J Surg. 1991; 21(4):480-4. DOI: 10.1007/BF02470981. View

16.

Sohda T, Hanano T, Miyamoto H, Kitano Y, Iwata K, Yokoyama M . Spontaneous rupture of metastatic alpha-fetoprotein-producing gastric cancer of the liver. Hepatol Int. 2009; 2(2):258-61. PMC: 2716845. DOI: 10.1007/s12072-008-9072-3. View

17.

Gulati A, Vyas S, Lal A, Harsha T S, Gupta V, Nijhawan R . Spontaneous rupture of hepatic metastasis from choriocarcinoma: a review of imaging and management. Ann Hepatol. 2009; 8(4):384-7. View

18.

Ueda K, Matsui H, Watanabe T, Seki J, Ichinohe T, Tsuji Y . Spontaneous rupture of liver plasmacytoma mimicking hepatocellular carcinoma. Intern Med. 2010; 49(7):653-7. DOI: 10.2169/internalmedicine.49.3103. View

19.

Chun H, Osuga K, Fahrni M, Nakamura H . Massive bleeding of ruptured metastatic hepatic melanoma treated by transarterial embolization. Jpn J Radiol. 2010; 28(5):395-7. DOI: 10.1007/s11604-010-0441-1. View

20.

Yampolski I, Ziv Y . Massive haemoperitoneum complicating metastasis in the liver. Eur J Surg Oncol. 1990; 16(5):462-3. View