Characterization of Macrophages Elicited by Intraperitoneal Injection of Hyaluronate

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1986 Aug 1

PMID 3020940

Citations 3

Authors

D Ponzin

P Vecchia

G Toffano

C Giordano

A Bruni

Affiliations

Soon will be listed here.

Abstract

Hyaluronate of 120,000 molecular weight has been injected in the peritoneal cavity of mice to study its effect on migration of inflammatory cells in vivo. After one day a dose-dependent granulocyte migration is observed. Three days later the number of granulocytes is greatly reduced and macrophages form about half of the total cell population. Hyaluronate-elicited macrophages show a decreased 5'-nucleotidase and an increased acid phosphatase activity as compared to resident macrophages. The production of superoxide anion in response to the phorbol ester tetradecanoyl-phorbolacetate, and the phagocytic activity are also enhanced. Macrophages elicited by hyaluronate secrete growth factor(s) for non-lymphoid mesenchymal cells. It is concluded that hyaluronate in vivo stimulates the migration of inflammatory cells, thus causing the recruitment of a population of stimulating macrophages. These effects may explain previous reports on the acceleration of wound healing by hyaluronate.

Citing Articles

Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammation.

Jameson J, Cauvi G, Sharp L, Witherden D, Havran W J Exp Med. 2005; 201(8):1269-79.

PMID: 15837812 PMC: 2213158. DOI: 10.1084/jem.20042057.

Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing.

Goa K, Benfield P Drugs. 1994; 47(3):536-66.

PMID: 7514978 DOI: 10.2165/00003495-199447030-00009.

Sodium hyaluronate increases vascular ingrowth in the rabbit ear chamber.

Lebel L, Gerdin B Int J Exp Pathol. 1991; 72(2):111-8.

PMID: 1707647 PMC: 2002300.

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