Experience-related Reductions of Myelin and Axon Diameter in Adulthood

Overview

Journal J Neurophysiol

Publisher American Physiological Society

Specialties Neurology
Physiology

Date 2018 Sep 13

PMID 30207857

Citations 9

Authors

Alberto Lazari

Sigrid Koudelka

Cassandra Sampaio-Baptista

Affiliations

Soon will be listed here.

Abstract

The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, Heß M, Grothe B, Leibold C, and Kopp-Scheinpflug C. J Neurosci 37: 8239-8255, 2017) have shown that auditory deprivation can lead to decrease in myelination and axon caliber even in healthy adulthood. These findings show that activity-regulated myelination is more complex than previously thought and expand our knowledge of how adult brain plasticity could operate on a cellular level.

Citing Articles

[Myelination as a modulating factor in memory circuitry].

Garcia-Montes M, Crespo I Rev Neurol. 2023; 76(3):101-109.

PMID: 36703503 PMC: 10364045. DOI: 10.33588/rn.7603.2022325.

Remodelling of myelinated axons and oligodendrocyte differentiation is stimulated by environmental enrichment in the young adult brain.

Nicholson M, Wood R, Gonsalvez D, Hannan A, Fletcher J, Xiao J Eur J Neurosci. 2022; 56(12):6099-6114.

PMID: 36217300 PMC: 10092722. DOI: 10.1111/ejn.15840.

A macroscopic link between interhemispheric tract myelination and cortico-cortical interactions during action reprogramming.

Lazari A, Salvan P, Verhagen L, Cottaar M, Papp D, van der Werf O Nat Commun. 2022; 13(1):4253.

PMID: 35869067 PMC: 9307658. DOI: 10.1038/s41467-022-31687-5.

Hebbian activity-dependent plasticity in white matter.

Lazari A, Salvan P, Cottaar M, Papp D, Rushworth M, Johansen-Berg H Cell Rep. 2022; 39(11):110951.

PMID: 35705046 PMC: 9376741. DOI: 10.1016/j.celrep.2022.110951.

White matter diffusivity and its correlations to state measures of psychopathology in male refugees with posttraumatic stress disorder.

Uldall S, Lundell H, Baare W, Siebner H, Rostrup E, Carlsson J Neuroimage Clin. 2022; 33:102929.

PMID: 34998125 PMC: 8741622. DOI: 10.1016/j.nicl.2021.102929.

References

Sinclair J, Fischl M, Alexandrova O, HeB M, Grothe B, Leibold C . Sound-Evoked Activity Influences Myelination of Brainstem Axons in the Trapezoid Body. J Neurosci. 2017; 37(34):8239-8255. PMC: 5566870. DOI: 10.1523/JNEUROSCI.3728-16.2017. View

Mensch S, Baraban M, Almeida R, Czopka T, Ausborn J, El Manira A . Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nat Neurosci. 2015; 18(5):628-30. PMC: 4427868. DOI: 10.1038/nn.3991. View

Arancibia-Carcamo I, Ford M, Cossell L, Ishida K, Tohyama K, Attwell D . Node of Ranvier length as a potential regulator of myelinated axon conduction speed. Elife. 2017; 6. PMC: 5313058. DOI: 10.7554/eLife.23329. View

Chereau R, Ezequiel Saraceno G, Angibaud J, Cattaert D, Nagerl U . Superresolution imaging reveals activity-dependent plasticity of axon morphology linked to changes in action potential conduction velocity. Proc Natl Acad Sci U S A. 2017; 114(6):1401-1406. PMC: 5307438. DOI: 10.1073/pnas.1607541114. View

Ford M, Alexandrova O, Cossell L, Stange-Marten A, Sinclair J, Kopp-Scheinpflug C . Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing. Nat Commun. 2015; 6:8073. PMC: 4560803. DOI: 10.1038/ncomms9073. View

Lehmann M, Weigel T, Elkahloun A, Herkenham M . Chronic social defeat reduces myelination in the mouse medial prefrontal cortex. Sci Rep. 2017; 7:46548. PMC: 5394533. DOI: 10.1038/srep46548. View

Etxeberria A, Hokanson K, Dao D, Mayoral S, Mei F, Redmond S . Dynamic Modulation of Myelination in Response to Visual Stimuli Alters Optic Nerve Conduction Velocity. J Neurosci. 2016; 36(26):6937-48. PMC: 4926240. DOI: 10.1523/JNEUROSCI.0908-16.2016. View

Sampaio-Baptista C, Johansen-Berg H . White Matter Plasticity in the Adult Brain. Neuron. 2017; 96(6):1239-1251. PMC: 5766826. DOI: 10.1016/j.neuron.2017.11.026. View

Jeffries M, Urbanek K, Torres L, Wendell S, Rubio M, Fyffe-Maricich S . ERK1/2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function. J Neurosci. 2016; 36(35):9186-200. PMC: 5005725. DOI: 10.1523/JNEUROSCI.1444-16.2016. View

10.

Lee Y, Morrison B, Li Y, Lengacher S, Farah M, Hoffman P . Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature. 2012; 487(7408):443-8. PMC: 3408792. DOI: 10.1038/nature11314. View

11.

Fields R . A new mechanism of nervous system plasticity: activity-dependent myelination. Nat Rev Neurosci. 2015; 16(12):756-67. PMC: 6310485. DOI: 10.1038/nrn4023. View

12.

Lee S, Leach M, Redmond S, Chong S, Mellon S, Tuck S . A culture system to study oligodendrocyte myelination processes using engineered nanofibers. Nat Methods. 2012; 9(9):917-22. PMC: 3433633. DOI: 10.1038/nmeth.2105. View

13.

Langer N, Hanggi J, Muller N, Simmen H, Jancke L . Effects of limb immobilization on brain plasticity. Neurology. 2012; 78(3):182-8. DOI: 10.1212/WNL.0b013e31823fcd9c. View

14.

Jevtovic-Todorovic V, Hartman R, Izumi Y, Benshoff N, Dikranian K, Zorumski C . Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci. 2003; 23(3):876-82. PMC: 6741934. View