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Identification of a Bromodomain-containing Protein 2 Gene Polymorphic Variant and Its Effects on Pork Quality Traits in Berkshire Pigs

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Specialty Biotechnology
Date 2018 Sep 13
PMID 30206429
Citations 1
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Abstract

Bromodomain-containing protein 2 is a nuclear serine/threonine kinase involved in transcriptional regulation. We investigated the expression and association of the gene as a candidate gene for meat quality traits in Berkshire pigs. mRNA was expressed at relatively high levels in muscle tissue. Statistical analysis revealed that the c.1709G>C polymorphism of the gene was significantly associated with carcass weight, meat color (a*, redness), protein content, cooking loss, water-holding capacity, carcass temperatures 4, 12 and 24 h postmortem, and the 24 h postmortem pH in 384 Berkshire pigs. Therefore, this polymorphism in the porcine gene may be used as a candidate genetic marker to improve meat quality traits in pigs.

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References
1.
Shang E, Cui Q, Wang X, Beseler C, Greenberg D, Wolgemuth D . The bromodomain-containing gene BRD2 is regulated at transcription, splicing, and translation levels. J Cell Biochem. 2011; 112(10):2784-93. PMC: 3178676. DOI: 10.1002/jcb.23192. View

2.
Taniguchi Y, Matsuzaka Y, Fujimoto H, Miyado K, Kohda A, Okumura K . Nucleotide sequence of the ring3 gene in the class II region of the mouse MHC and its abundant expression in testicular germ cells. Genomics. 1998; 51(1):114-23. DOI: 10.1006/geno.1998.5262. View

3.
Maribo H, Olsen E, Barton-Gade P, Moller A, Karlsson A . Effect of early post-mortem cooling on temperature, pH fall and meat quality in pigs. Meat Sci. 2011; 50(1):115-29. DOI: 10.1016/S0309-1740(98)00022-9. View

4.
Thorpe K, Beck S . DNA sequence and structure of the mouse RING3 gene: identification of variant RING3 transcripts. Immunogenetics. 1998; 48(1):82-6. DOI: 10.1007/s002510050406. View

5.
Denis G, Green M . A novel, mitogen-activated nuclear kinase is related to a Drosophila developmental regulator. Genes Dev. 1996; 10(3):261-71. DOI: 10.1101/gad.10.3.261. View