The Current Understanding of Sarcopenia: Emerging Tools and Interventional Possibilities

Overview

Journal Am J Lifestyle Med

Publisher Sage Publications

Date 2018 Sep 12

PMID 30202329

Citations 14

Authors

Matthew J Delmonico

Darren T Beck

Affiliations

Soon will be listed here.

Abstract

The purpose of this review is to provide health practitioners and physicians the most current state of the research on sarcopenia, its consequences, and to offer a summary of consensus guidelines for identification based on the most recent and compelling investigations and analyses. To accomplish this, the causes and consequences of sarcopenia will be described, and definitions and screening methods are updated. Importantly, interventional recommendations for sarcopenia will be discussed with a special emphasis on the effects of resistance training on sarcopenia-related outcomes. Furthermore, due to the increasing usage of hormone treatment as a strategy to combat sarcopenia, special consideration on the effects of hormone changes with aging and as interventions will be briefly reviewed.

Citing Articles

Recent Update on the Prevalence of Sarcopenia in Koreans: Findings from the Korea National Health and Nutrition Examination Survey.

Kim S, Ha Y, Kim D, Yoo J J Bone Metab. 2024; 31(2):150-161.

PMID: 38886972 PMC: 11184149. DOI: 10.11005/jbm.2024.31.2.150.

Sarcopenia as a Risk Factor for Alzheimer's Disease: Genetic and Epigenetic Perspectives.

Raleigh S, Orchard K Genes (Basel). 2024; 15(5).

PMID: 38790190 PMC: 11121242. DOI: 10.3390/genes15050561.

Evaluation of the association between osteoporotic vertebral compression fractures and psoas major/paraspinal muscle mass and ADC measured on MRI.

Tokashiki T, Igarashi T, Shiraishi M, Kano R, Ojiri H Skeletal Radiol. 2023; 53(4):675-682.

PMID: 37831148 DOI: 10.1007/s00256-023-04461-x.

Targeting Crosstalk of Signaling Pathways among Muscles-Bone-Adipose Tissue: A Promising Therapeutic Approach for Sarcopenia.

Sharma A, Chatterjee S, Lee Y, Lee S Aging Dis. 2023; 15(4):1619-1645.

PMID: 37815907 PMC: 11272187. DOI: 10.14336/AD.2023.00903.

Relationship between DNA methylation changes and skeletal muscle mass.

Gim J, Lee S, Kim S, Baek K, Seo S, Yoo J BMC Genom Data. 2023; 24(1):48.

PMID: 37653517 PMC: 10472633. DOI: 10.1186/s12863-023-01152-3.

References

Pereira A, Costa A, Izquierdo M, Silva A, Bastos E, Marques M . ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli. Age (Dordr). 2012; 35(5):1949-59. PMC: 3776118. DOI: 10.1007/s11357-012-9461-3. View

Iannuzzi-Sucich M, Prestwood K, Kenny A . Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci. 2002; 57(12):M772-7. DOI: 10.1093/gerona/57.12.m772. View

Rantanen T, Guralnik J, Ferrucci L, Leveille S, Fried L . Coimpairments: strength and balance as predictors of severe walking disability. J Gerontol A Biol Sci Med Sci. 1999; 54(4):M172-6. DOI: 10.1093/gerona/54.4.m172. View

Dam T, Peters K, Fragala M, Cawthon P, Harris T, McLean R . An evidence-based comparison of operational criteria for the presence of sarcopenia. J Gerontol A Biol Sci Med Sci. 2014; 69(5):584-90. PMC: 3991139. DOI: 10.1093/gerona/glu013. View

Wolfe R, Miller S, Miller K . Optimal protein intake in the elderly. Clin Nutr. 2008; 27(5):675-84. DOI: 10.1016/j.clnu.2008.06.008. View

Hodis H, Mack W, Lobo R, Shoupe D, Sevanian A, MAHRER P . Estrogen in the prevention of atherosclerosis. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 2001; 135(11):939-53. DOI: 10.7326/0003-4819-135-11-200112040-00005. View

Nair K, Rizza R, OBrien P, Dhatariya K, Short K, Nehra A . DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med. 2006; 355(16):1647-59. DOI: 10.1056/NEJMoa054629. View

Page S, Amory J, Bowman F, Anawalt B, Matsumoto A, Bremner W . Exogenous testosterone (T) alone or with finasteride increases physical performance, grip strength, and lean body mass in older men with low serum T. J Clin Endocrinol Metab. 2004; 90(3):1502-10. DOI: 10.1210/jc.2004-1933. View

Earles D, Judge J, Gunnarsson O . Velocity training induces power-specific adaptations in highly functioning older adults. Arch Phys Med Rehabil. 2001; 82(7):872-8. DOI: 10.1053/apmr.2001.23838. View

10.

Calof O, Singh A, Lee M, Kenny A, Urban R, Tenover J . Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo-controlled trials. J Gerontol A Biol Sci Med Sci. 2005; 60(11):1451-7. DOI: 10.1093/gerona/60.11.1451. View

11.

Bhasin S, Woodhouse L, Casaburi R, Singh A, Mac R, Lee M . Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. J Clin Endocrinol Metab. 2004; 90(2):678-88. DOI: 10.1210/jc.2004-1184. View

12.

Janssen I, Shepard D, Katzmarzyk P, Roubenoff R . The healthcare costs of sarcopenia in the United States. J Am Geriatr Soc. 2003; 52(1):80-5. DOI: 10.1111/j.1532-5415.2004.52014.x. View

13.

Anderson J, Adams C, Antman E, Bridges C, Califf R, Casey Jr D . ACC/AHA 2007 guidelines for the management of patients with unstable angina/non ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to.... Circulation. 2007; 116(7):e148-304. DOI: 10.1161/CIRCULATIONAHA.107.181940. View

14.

Anderson L, Erceg D, Schroeder E . Utility of multifrequency bioelectrical impedance compared with dual-energy x-ray absorptiometry for assessment of total and regional body composition varies between men and women. Nutr Res. 2012; 32(7):479-85. DOI: 10.1016/j.nutres.2012.05.009. View

15.

Wilson M, Purushothaman R, Morley J . Effect of liquid dietary supplements on energy intake in the elderly. Am J Clin Nutr. 2002; 75(5):944-7. DOI: 10.1093/ajcn/75.5.944. View

16.

Fried L, Tangen C, Walston J, Newman A, Hirsch C, Gottdiener J . Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001; 56(3):M146-56. DOI: 10.1093/gerona/56.3.m146. View

17.

McLean R, Shardell M, Alley D, Cawthon P, Fragala M, Harris T . Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: the foundation for the National Institutes of Health (FNIH) sarcopenia project. J Gerontol A Biol Sci Med Sci. 2014; 69(5):576-83. PMC: 3991140. DOI: 10.1093/gerona/glu012. View

18.

Baumgartner R, Waters D, Gallagher D, Morley J, Garry P . Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev. 1999; 107(2):123-36. DOI: 10.1016/s0047-6374(98)00130-4. View

19.

Petak S, Nankin H, Spark R, Swerdloff R, Rodriguez-Rigau L . American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients--2002 update. Endocr Pract. 2004; 8(6):440-56. View

20.

Fragala M, Dam T, Barber V, Judge J, Studenski S, Cawthon P . Strength and function response to clinical interventions of older women categorized by weakness and low lean mass using classifications from the Foundation for the National Institute of Health sarcopenia project. J Gerontol A Biol Sci Med Sci. 2014; 70(2):202-9. PMC: 4311186. DOI: 10.1093/gerona/glu110. View