The Effects of Zinc Amino Acid Complex Supplementation on the Porcine Host Response to Lawsonia Intracellularis Infection

Overview

Journal Vet Res

Publisher Biomed Central

Specialty Veterinary Medicine

Date 2018 Sep 12

PMID 30201036

Citations 5

Authors

Fernando L Leite

Erika Vasquez

Fabio A Vannucci

Connie J Gebhart

Aaron Rendahl

Jerry Torrison

Adam Mueller

Nathan L Winkelman

Zachary J Rambo

Richard E Isaacson

Affiliations

Soon will be listed here.

Abstract

Lawsonia intracellularis is among the most important enteric pathogens of swine and antibiotic alternatives are needed to help mitigate the negative effects of infection. Zinc is an essential trace mineral known to be crucial for maintaining intestinal barrier function and proper immune response. In this study, we investigated the porcine host response to L. intracellularis infection when supplemented with a zinc-amino acid complex, a form of zinc that can lead to greater bioavailability when compared to traditional inorganic forms of zinc. Our results show that a zinc-amino acid complex supplementation with a final concentration of 125 ppm of zinc in feed significantly (p < 0.05) decreased the number of animals with lesions and severity of lesions caused by L. intracellularis. Animals supplemented with the zinc-amino acid complex also exhibited a significantly (p < 0.05) earlier onset of seroconversion as well as an increased number of T cells in infected and non-infected intestinal tissue. This study demonstrated that this zinc-amino acid complex aids the host in responding to L. intracellularis infection and may be a new approach to help minimize negative effects of disease.

Citing Articles

Increased Effect of Foot-and-Mouth Disease Virus Vaccine Structural Protein Antibody Positivity Rates in Piglets Orally Treated with Amino-Zinc Complex.

Lee B, Lee H, Kim N, Kim Y, Park K Animals (Basel). 2023; 13(12).

PMID: 37370536 PMC: 10295135. DOI: 10.3390/ani13122027.

Recent Advances in Understanding the Influence of Zinc, Copper, and Manganese on the Gastrointestinal Environment of Pigs and Poultry.

Broom L, Monteiro A, Pinon A Animals (Basel). 2021; 11(5).

PMID: 33946674 PMC: 8145729. DOI: 10.3390/ani11051276.

Correlation of Lawsonia intracellularis positivity in quantitative PCR and herd factors in European pig herds.

Arnold M, Crienen A, Swam H, Berg S, Jolie R, Nathues H Porcine Health Manag. 2021; 7(1):13.

PMID: 33482877 PMC: 7821494. DOI: 10.1186/s40813-021-00192-4.

Analytical characterization of trace elements (zinc, copper, cadmium, lead and selenium) in saliva of pigs under common pathological conditions in the field: a pilot study.

Sanchez J, Montilla M, Gutierrez-Panizo C, Sotillo J, Fuentes P, Montes A BMC Vet Res. 2020; 16(1):27.

PMID: 32000745 PMC: 6993390. DOI: 10.1186/s12917-020-2245-6.

The Effects of Partially or Completely Substituted Dietary Zinc Sulfate by Lower Levels of Zinc Methionine on Growth Performance, Apparent Total Tract Digestibility, Immune Function, and Visceral Indices in Weaned Piglets.

Xie Y, Zhang Q, Wang L, Wang Y, Cheng Z, Yang Z Animals (Basel). 2019; 9(5).

PMID: 31086094 PMC: 6562981. DOI: 10.3390/ani9050236.

References

Yazdankhah S, Rudi K, Bernhoft A . Zinc and copper in animal feed - development of resistance and co-resistance to antimicrobial agents in bacteria of animal origin. Microb Ecol Health Dis. 2014; 25. PMC: 4179321. DOI: 10.3402/mehd.v25.25862. View

Bonaventura P, Benedetti G, Albarede F, Miossec P . Zinc and its role in immunity and inflammation. Autoimmun Rev. 2014; 14(4):277-85. DOI: 10.1016/j.autrev.2014.11.008. View

Guedes R, Gebhart C, Deen J, Winkelman N . Validation of an immunoperoxidase monolayer assay as a serologic test for porcine proliferative enteropathy. J Vet Diagn Invest. 2002; 14(6):528-30. DOI: 10.1177/104063870201400618. View

Tuerk M, Fazel N . Zinc deficiency. Curr Opin Gastroenterol. 2009; 25(2):136-43. DOI: 10.1097/MOG.0b013e328321b395. View

Lee C, Humphrey P . Interaction of nutrition and infection: effect of zinc deficiency on immunoglobulin levels in trypanosoma musculi infection. J Natl Med Assoc. 1983; 75(7):677-82. PMC: 2561480. View

Davin R, Manzanilla E, Klasing K, Perez J . Effect of weaning and in-feed high doses of zinc oxide on zinc levels in different body compartments of piglets. J Anim Physiol Anim Nutr (Berl). 2013; 97 Suppl 1:6-12. DOI: 10.1111/jpn.12046. View

Payne R, Bidner T, Fakler T, Southern L . Growth and intestinal morphology of pigs from sows fed two zinc sources during gestation and lactation. J Anim Sci. 2006; 84(8):2141-9. DOI: 10.2527/jas.2005-627. View

Haase H, Rink L . Multiple impacts of zinc on immune function. Metallomics. 2014; 6(7):1175-80. DOI: 10.1039/c3mt00353a. View

MacIntyre N, Smith D, Shaw D, Thomson J, Rhind S . Immunopathogenesis of experimentally induced proliferative enteropathy in pigs. Vet Pathol. 2003; 40(4):421-32. DOI: 10.1354/vp.40-4-421. View

10.

Wedekind K, Hortin A, Baker D . Methodology for assessing zinc bioavailability: efficacy estimates for zinc-methionine, zinc sulfate, and zinc oxide. J Anim Sci. 1992; 70(1):178-87. DOI: 10.2527/1992.701178x. View

11.

Lawson G, Gebhart C . Proliferative enteropathy. J Comp Pathol. 2000; 122(2-3):77-100. DOI: 10.1053/jcpa.1999.0347. View

12.

Fraker P, King L, Laakko T, Vollmer T . The dynamic link between the integrity of the immune system and zinc status. J Nutr. 2000; 130(5S Suppl):1399S-406S. DOI: 10.1093/jn/130.5.1399S. View

13.

Cario E, Jung S, Harder dHeureuse J, Schulte C, Sturm A, Wiedenmann B . Effects of exogenous zinc supplementation on intestinal epithelial repair in vitro. Eur J Clin Invest. 2000; 30(5):419-28. DOI: 10.1046/j.1365-2362.2000.00618.x. View

14.

Guedes R, Gebhart C, Winkelman N, Marsteller T, Deen J . Comparison of different methods for diagnosis of porcine proliferative enteropathy. Can J Vet Res. 2002; 66(2):99-107. PMC: 226990. View

15.

Alam A, Sarker S, Wahed M, Khatun M, Rahaman M . Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation. Gut. 1994; 35(12):1707-11. PMC: 1375257. DOI: 10.1136/gut.35.12.1707. View

16.

Fraker P, King L . Reprogramming of the immune system during zinc deficiency. Annu Rev Nutr. 2004; 24:277-98. DOI: 10.1146/annurev.nutr.24.012003.132454. View

17.

Helm E, Outhouse A, Schwartz K, Dekkers J, Lonergan S, Rauw W . Impact of Mycoplasma hyopneumoniae and Lawsonia intracellularis on the performance of pigs divergently selected for feed efficiency. J Anim Sci. 2018; 96(2):462-472. PMC: 6140898. DOI: 10.1093/jas/skx074. View

18.

Bajait C, Thawani V . Role of zinc in pediatric diarrhea. Indian J Pharmacol. 2011; 43(3):232-5. PMC: 3113371. DOI: 10.4103/0253-7613.81495. View

19.

Pearce S, Sanz Fernandez M, Torrison J, Wilson M, Baumgard L, Gabler N . Dietary organic zinc attenuates heat stress-induced changes in pig intestinal integrity and metabolism. J Anim Sci. 2015; 93(10):4702-13. DOI: 10.2527/jas.2015-9018. View

20.

Rahman M, Sarker P, Roy S, Ahmad S, Chisti J, Azim T . Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis. Am J Clin Nutr. 2005; 81(2):495-502. DOI: 10.1093/ajcn.81.2.495. View