Obstructive Sleep Apnea and Severity of Coronary Artery Disease

Overview

Journal Caspian J Intern Med

Specialty General Medicine

Date 2018 Sep 11

PMID 30197773

Citations 16

Authors

Ali Vasheghani-Farahani

Fatemeh Kazemnejad

Khosro Sadeghniiat-Haghighi

Soleil Saadat

Parya Tavakolipoor

Tahereh Yazdani

Mohammad Alidoosti

Vahid Ghasem-Amooeian

Haleh Ashraf

Affiliations

Soon will be listed here.

Abstract

Background: It has been implicated that obstructive sleep apnea (OSA) is associated with increased risk of cardiovascular disease including stroke, myocardial infarction, coronary artery disease (CAD) and hypertension. The aim of this study was to investigate the correlation between OSA and severity of atherosclerosis assessed by angiography.

Methods: This study included 337 patients undergoing diagnostic coronary angiography at Tehran Heart Center, Iran. The Gensini score was obtained from each patient for coronary angiogram, and OSA were assessed by using Multivariable apnea prediction (MAP) risk index on the day of cardiac catheterization. The Gensini scores increased in accordance with increases in the MAP value.

Results: The prevalence rates of three-vessel disease were 68.0% in OSA group and 32.0% in non-OSA group. The MAP index was the most significant independent determinant for the Gensini score.

Conclusions: The independent association between OSA and CAD, even after adjustment for traditional confounders, suggests that, OSA should be taken into account when considering risk factors for CAD.

Citing Articles

Associations of TyG index with coronary heart disease risk and coronary artery sclerosis severity in OSA.

Qiu X, Aimaiti G, Chen Y, Li Y, Sun X Diabetol Metab Syndr. 2024; 16(1):301.

PMID: 39696382 PMC: 11657963. DOI: 10.1186/s13098-024-01545-z.

The Impact of Coronary Artery Disease on Outcomes in Patients With Peripartum Cardiomyopathy.

Elkattawy O, Phansalkar J, Elkattawy S, Mohamed O, Javed J, Hossain A Cureus. 2024; 16(4):e59269.

PMID: 38813289 PMC: 11135137. DOI: 10.7759/cureus.59269.

Unveiling HPV's hidden link: Cardiovascular diseases and the viral intrigue.

Dutta P, Saha D, Earle M, Prasad C, Singh M, Darswal M Indian Heart J. 2024; 76(1):1-5.

PMID: 38387552 PMC: 10943540. DOI: 10.1016/j.ihj.2024.02.001.

Investigate the relationship between obstructive sleep apnea and cardiac arrhythmia after CABG surgery.

Mohammadi S, Paryad E, Khanghah A, Leili E, Noveiri M BMC Cardiovasc Disord. 2024; 24(1):64.

PMID: 38263001 PMC: 10804646. DOI: 10.1186/s12872-023-03694-x.

Obstructive sleep apnea: a follow-up program in its relation to temporomandibular joint disorder, sleep bruxism and orofacial pain.

Ning R, Chen J, Lu Y, Guo J BMC Oral Health. 2023; 23(1):578.

PMID: 37598191 PMC: 10440039. DOI: 10.1186/s12903-023-03264-9.

References

Nadeem R, Singh M, Nida M, Kwon S, Sajid H, Witkowski J . Effect of CPAP treatment for obstructive sleep apnea hypopnea syndrome on lipid profile: a meta-regression analysis. J Clin Sleep Med. 2014; 10(12):1295-302. PMC: 4237522. DOI: 10.5664/jcsm.4282. View

Ito E, Tsuiki S, Maeda K, Okajima I, Inoue Y . Oropharyngeal Crowding Closely Relates to Aggravation of OSA. Chest. 2016; 150(2):346-52. DOI: 10.1016/j.chest.2016.03.005. View

Mohsenin V . Obstructive sleep apnea: a new preventive and therapeutic target for stroke: a new kid on the block. Am J Med. 2015; 128(8):811-6. DOI: 10.1016/j.amjmed.2015.01.037. View

Palma J, Iriarte J, Fernandez S, Alegre M, Valencia M, Artieda J . Long-term continuous positive airway pressure therapy improves cardiac autonomic tone during sleep in patients with obstructive sleep apnea. Clin Auton Res. 2015; 25(4):225-32. DOI: 10.1007/s10286-015-0297-7. View

Shamsuzzaman A, Gersh B, Somers V . Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003; 290(14):1906-14. DOI: 10.1001/jama.290.14.1906. View

Ali S, Oni E, Warraich H, Blaha M, Blumenthal R, Karim A . Systematic review on noninvasive assessment of subclinical cardiovascular disease in obstructive sleep apnea: new kid on the block!. Sleep Med Rev. 2014; 18(5):379-91. DOI: 10.1016/j.smrv.2014.01.004. View

Cepeda-Valery B, Acharjee S, Romero-Corral A, Pressman G, Gami A . Obstructive sleep apnea and acute coronary syndromes: etiology, risk, and management. Curr Cardiol Rep. 2014; 16(10):535. DOI: 10.1007/s11886-014-0535-y. View

Olea E, Agapito M, Gallego-Martin T, Rocher A, Gomez-Nino A, Obeso A . Intermittent hypoxia and diet-induced obesity: effects on oxidative status, sympathetic tone, plasma glucose and insulin levels, and arterial pressure. J Appl Physiol (1985). 2014; 117(7):706-19. DOI: 10.1152/japplphysiol.00454.2014. View

Anandam A, Patil M, Akinnusi M, Jaoude P, El-Solh A . Cardiovascular mortality in obstructive sleep apnoea treated with continuous positive airway pressure or oral appliance: an observational study. Respirology. 2013; 18(8):1184-90. DOI: 10.1111/resp.12140. View

10.

Cassar A, Morgenthaler T, Lennon R, Rihal C, Lerman A . Treatment of obstructive sleep apnea is associated with decreased cardiac death after percutaneous coronary intervention. J Am Coll Cardiol. 2007; 50(14):1310-4. DOI: 10.1016/j.jacc.2007.06.028. View

11.

Dyugovskaya L, Lavie P, Lavie L . Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med. 2002; 165(7):934-9. DOI: 10.1164/ajrccm.165.7.2104126. View

12.

Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K . Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation;.... Circulation. 2009; 120(16):1640-5. DOI: 10.1161/CIRCULATIONAHA.109.192644. View

13.

Marin J, Agusti A, Villar I, Forner M, Nieto D, Carrizo S . Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA. 2012; 307(20):2169-76. PMC: 4657563. DOI: 10.1001/jama.2012.3418. View

14.

Ramachandran S, Josephs L . A meta-analysis of clinical screening tests for obstructive sleep apnea. Anesthesiology. 2009; 110(4):928-39. DOI: 10.1097/ALN.0b013e31819c47b6. View

15.

Al Mutairi S, Mojiminiyi O, Al Alawi A, Al Rammah T, Abdella N . Study of leptin and adiponectin as disease markers in subjects with obstructive sleep apnea. Dis Markers. 2014; 2014:706314. PMC: 4058890. DOI: 10.1155/2014/706314. View

16.

Yang D, Liu Z, Yang H, Luo Q . Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis. Sleep Breath. 2012; 17(1):33-8. DOI: 10.1007/s11325-012-0680-8. View

17.

Peppard P, Young T, Barnet J, Palta M, Hagen E, Hla K . Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013; 177(9):1006-14. PMC: 3639722. DOI: 10.1093/aje/kws342. View

18.

Lu G, Xu Z, Zhang Y, Yang Z, Zhang X, Yin K . Correlation among obstructive sleep apnea syndrome, coronary atherosclerosis and coronary heart disease. Chin Med J (Engl). 2007; 120(18):1632-4. View

19.

Becker H, Jerrentrup A, Ploch T, Grote L, Penzel T, Sullivan C . Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation. 2003; 107(1):68-73. DOI: 10.1161/01.cir.0000042706.47107.7a. View

20.

Murphy A, Thomas A, Crinion S, Kent B, Tambuwala M, Fabre A . Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation. Eur Respir J. 2017; 49(4). DOI: 10.1183/13993003.01731-2016. View