Dysregulated Fatty Acid Metabolism in Hepatocellular Carcinoma

Overview

Journal Hepat Oncol

Date 2018 Sep 8

PMID 30191046

Citations 46

Authors

Mingda Wang

Jun Han

Hao Xing

Han Zhang

Zhenli Li

Lei Liang

Chao Li

Shuyang Dai

Mengchao Wu

Feng Shen

Tian Yang

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is one of the most frequent and deadly malignancies worldwide. Studies are urgently needed on its molecular pathogenesis and biological characteristics. Dysregulation of fatty acid (FA) metabolism, in which aberrant activation of oncogenic signaling pathways alters the expression and activity of lipid-metabolizing enzymes, is an emerging hallmark of cancer cells, and it may be involved in HCC development and progression. The current review summarizes what is known about dysregulated FA metabolism in HCC and pathways through which this dysregulation may regulate HCC survival and growth. Our understanding of dysregulated FA metabolism and associated signaling pathways may contribute to the development of novel and efficient antitumor approaches for patients with HCC.

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