Evaluation of Early Renal Damage in Type 2 Diabetic Patients on 3.0 T MR Diffusion Tensor Imaging

Overview

Journal World J Radiol

Publisher Baishideng Publishing Group

Specialty Radiology

Date 2018 Sep 8

PMID 30190800

Citations 1

Authors

Yu-Ting Wang

Xiong Yan

Hong Pu

Long-Lin Yin

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the utility of renal diffusion tensor imaging (DTI) to detect early renal damage in patients with type 2 diabetes.

Methods: Twenty-six diabetic patients (12 with microalbuminuria (MAU), and 14 with normoalbuminuria) and fourteen healthy volunteers were prospectively included in this study. Renal DTI on 3.0 T MR was performed, and estimated glomerular filtration rate (eGFR) was recorded for each subject. Mean cortical and medullary fractional anisotropy (FA) values were calculated by placing multiple representative regions of interest. Mean FA values were statistically compared among groups. Correlations between FA values and eGFR were evaluated.

Results: Both cortical and medullary FA were significantly reduced in diabetic patients compared to healthy controls (0.403 ± 0.064 0.463 ± 0.047, = 0.004, and 0.556 ± 0.084 0.645 ± 0.076, = 0.002, respectively). Cortical FA was significantly lower in diabetic patients with NAU than healthy controls (0.412 ± 0.068 0.463 ± 0.047, = 0.02). Medullary FA in diabetic patients with NAU and healthy controls were similar (0.582 ± 0.096 0.645 ± 0.076, = 0.06). Both cortical FA and medullary FA correlated with eGFR ( = 0.382, = 0.015 and = 0.552, = 0.000, respectively).

Conclusion: FA of renal parenchyma on DTI might serve as a more sensitive biomarker of early diabetic nephropathy than MAU.

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