Death of by L-arginine Starvation

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2018 Sep 8

PMID 30190428

Citations 7

Authors

Valerie Mizrahi

Digby F Warner

Affiliations

Soon will be listed here.

Citing Articles

Efficacy of pH-Responsive Surface Functionalized Titanium Screws in Treating Implant-associated S. aureus Osteomyelitis with Biofilms Formation.

Zhou H, Ren Y, Zou K, Jin Y, Liu H, Jiang H Adv Healthc Mater. 2024; 14(3):e2403261.

PMID: 39604325 PMC: 11773098. DOI: 10.1002/adhm.202403261.

Amino Acid Biosynthesis Inhibitors in Tuberculosis Drug Discovery.

Guida M, Tammaro C, Quaranta M, Salvucci B, Biava M, Poce G Pharmaceutics. 2024; 16(6).

PMID: 38931847 PMC: 11206623. DOI: 10.3390/pharmaceutics16060725.

New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis.

Zhang K, Mishra A, Jagannath C Front Immunol. 2024; 15:1363938.

PMID: 38605962 PMC: 11008464. DOI: 10.3389/fimmu.2024.1363938.

Regulated Arginine Metabolism in Immunopathogenesis of a Wide Range of Diseases: Is There a Way to Pass between Scylla and Charybdis?.

Starikova E, Rubinstein A, Mammedova J, Isakov D, Kudryavtsev I Curr Issues Mol Biol. 2023; 45(4):3525-3551.

PMID: 37185755 PMC: 10137093. DOI: 10.3390/cimb45040231.

Metabolic Profiles of Clinical Isolates of Drug-Susceptible and Multidrug-Resistant : A Metabolomics-Based Study.

Wang L, Ying R, Liu Y, Sun Q, Sha W Infect Drug Resist. 2023; 16:2667-2680.

PMID: 37163145 PMC: 10164396. DOI: 10.2147/IDR.S405987.

References

Park Y, Pacitto A, Bayliss T, Cleghorn L, Wang Z, Hartman T . Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis. ACS Infect Dis. 2016; 3(1):18-33. PMC: 5972394. DOI: 10.1021/acsinfecdis.6b00103. View

Trapero A, Pacitto A, Singh V, Sabbah M, Coyne A, Mizrahi V . Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis. J Med Chem. 2018; 61(7):2806-2822. PMC: 5900554. DOI: 10.1021/acs.jmedchem.7b01622. View

Evans J, Mizrahi V . Priming the tuberculosis drug pipeline: new antimycobacterial targets and agents. Curr Opin Microbiol. 2018; 45:39-46. DOI: 10.1016/j.mib.2018.02.006. View

Wellington S, Hung D . The Expanding Diversity of Mycobacterium tuberculosis Drug Targets. ACS Infect Dis. 2018; 4(5):696-714. DOI: 10.1021/acsinfecdis.7b00255. View

Vilcheze C, Hartman T, Weinrick B, Jacobs Jr W . Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction. Nat Commun. 2013; 4:1881. PMC: 3698613. DOI: 10.1038/ncomms2898. View

Dwyer D, Collins J, Walker G . Unraveling the physiological complexities of antibiotic lethality. Annu Rev Pharmacol Toxicol. 2014; 55:313-32. DOI: 10.1146/annurev-pharmtox-010814-124712. View

Zhang Y, Reddy M, Ioerger T, Rothchild A, Dartois V, Schuster B . Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell. 2013; 155(6):1296-308. PMC: 3902092. DOI: 10.1016/j.cell.2013.10.045. View

Mishra A, Mamidi A, Rajmani R, Ray A, Roy R, Surolia A . An allosteric inhibitor of ArgJ: Implications to a novel combinatorial therapy. EMBO Mol Med. 2018; 10(4). PMC: 5887547. DOI: 10.15252/emmm.201708038. View

Gordhan B, Smith D, Alderton H, McAdam R, Bancroft G, Mizrahi V . Construction and phenotypic characterization of an auxotrophic mutant of Mycobacterium tuberculosis defective in L-arginine biosynthesis. Infect Immun. 2002; 70(6):3080-4. PMC: 127984. DOI: 10.1128/IAI.70.6.3080-3084.2002. View

10.

Evans J, Trujillo C, Wang Z, Eoh H, Ehrt S, Schnappinger D . Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis. ACS Infect Dis. 2016; 2(12):958-968. PMC: 5153693. DOI: 10.1021/acsinfecdis.6b00150. View

11.

Awasthi D, Freundlich J . Antimycobacterial Metabolism: Illuminating Mycobacterium tuberculosis Biology and Drug Discovery. Trends Microbiol. 2017; 25(9):756-767. PMC: 5564221. DOI: 10.1016/j.tim.2017.05.007. View

12.

Tiwari S, van Tonder A, Vilcheze C, Mendes V, Thomas S, Malek A . Arginine-deprivation-induced oxidative damage sterilizes . Proc Natl Acad Sci U S A. 2018; 115(39):9779-9784. PMC: 6166831. DOI: 10.1073/pnas.1808874115. View

13.

Botella L, Vaubourgeix J, Livny J, Schnappinger D . Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death. Nat Commun. 2017; 8():14731. PMC: 5379054. DOI: 10.1038/ncomms14731. View

14.

Mdluli K, Kaneko T, Upton A . The tuberculosis drug discovery and development pipeline and emerging drug targets. Cold Spring Harb Perspect Med. 2015; 5(6). PMC: 4448709. DOI: 10.1101/cshperspect.a021154. View

15.

Fauci A, Eisinger R . Reimagining the Research Approach to Tuberculosis. Am J Trop Med Hyg. 2018; 98(3):650-652. PMC: 5930924. DOI: 10.4269/ajtmh.17-0999. View

16.

Berney M, Berney-Meyer L, Wong K, Chen B, Chen M, Kim J . Essential roles of methionine and S-adenosylmethionine in the autarkic lifestyle of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2015; 112(32):10008-13. PMC: 4538671. DOI: 10.1073/pnas.1513033112. View

17.

Abrahams G, Kumar A, Savvi S, Hung A, Wen S, Abell C . Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. Chem Biol. 2012; 19(7):844-54. PMC: 3421836. DOI: 10.1016/j.chembiol.2012.05.020. View

18.

Fan X, Tang B, Xu Y, Han A, Shi K, Wu Y . Oxidation of dCTP contributes to antibiotic lethality in stationary-phase mycobacteria. Proc Natl Acad Sci U S A. 2018; 115(9):2210-2215. PMC: 5834715. DOI: 10.1073/pnas.1719627115. View

19.

Wellington S, Nag P, Michalska K, Johnston S, Jedrzejczak R, Kaushik V . A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat Chem Biol. 2017; 13(9):943-950. PMC: 6886523. DOI: 10.1038/nchembio.2420. View