Early Signals in the Mitogenic Response

Overview

Journal Science

Specialty Science

Date 1986 Oct 10

PMID 3018928

Citations 261

Authors

E Rozengurt

Affiliations

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Abstract

Polypeptide growth factors, regulatory peptides, and a variety of pharmacological agents acting alone or synergistically induce mitogenesis in cultured fibroblasts. The early signals in the membrane, cytosol, and nucleus promoted by these extracellular factors, together with their mitogenic effectiveness, are integrated in a unified hypothesis for the regulation of fibroblast growth.

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