Superoxide Generation by Synovial Fluid Neutrophils Enhanced by Immune Complexes and Suppressed by Rheumatoid Factor in Synovial Fluid

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 1986 Jan 1

PMID 3018908

Citations 3

Authors

T Todoroki

M Shingu

I Ezaki

M Nobunaga

Affiliations

Soon will be listed here.

Abstract

Synovial fluid (SF) from patients with rheumatoid arthritis (RA) enhanced superoxide generation by neutrophils isolated from RA SF, in contrast to SF from patients with osteoarthritis. These superoxide generation-enhancing substances may be intermediate-sized immune complexes and a complement C5-derived fragment. Rheumatoid factor (RF) isolated from RA SF suppressed superoxide generation-enhancing activity of aggregated IgG. Therefore, biologically active RF may block the interaction of the immune complexes with neutrophils accumulating in RA SF, and protect the joint tissue from the effects of oxygen radicals or proteases.

Citing Articles

Complement-activating properties of immune complexes are suppressed by IgM rheumatoid factor and enhanced by IgG rheumatoid factor.

Shingu M, Ezaki I, Nobunaga M Rheumatol Int. 1988; 8(3):95-100.

PMID: 3175453 DOI: 10.1007/BF00272429.

Generation of superoxide by immunologically stimulated normal human neutrophils and possible modulation by intracellular and extracellular SOD and rheumatoid factors.

Shingu M, Todoroki T, Nobunaga M Inflammation. 1987; 11(2):143-51.

PMID: 3034780 DOI: 10.1007/BF00916016.

Rheumatoid factor modulation of neutrophil superoxide generation enhancing activity of preformed immune complexes.

Oishi S, Shingu M, Ezaki I, Nobunaga M, Sakai K Rheumatol Int. 1990; 10(1):9-12.

PMID: 2162079 DOI: 10.1007/BF02274775.

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