Rab GTPases in Osteoclastic Endomembrane Systems

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2018 Sep 7

PMID 30186859

Citations 7

Authors

Michele Roy

Sophie Roux

Affiliations

Soon will be listed here.

Abstract

Osteoclasts (OCs) are bone-resorbing cells that maintain bone homeostasis. OC differentiation, survival, and activity are regulated by numerous small GTPases, including those of the Rab family, which are involved in plasma membrane delivery and lysosomal and autophagic degradation pathways. In resorbing OCs, polarized vesicular trafficking pathways also result in formation of the ruffled membrane, the resorbing organelle, and in transcytosis.

Citing Articles

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A missense mouse model for Smith-McCort dysplasia shows bone resorption defects and altered protein glycosylation.

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The lysosomal V-ATPase a3 subunit is involved in localization of Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts.

Matsumoto N, Sekiya M, Sun-Wada G, Wada Y, Nakanishi-Matsui M Sci Rep. 2022; 12(1):8455.

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Membrane Transport Proteins in Osteoclasts: The Ins and Outs.

Ribet A, Ng P, Pavlos N Front Cell Dev Biol. 2021; 9:644986.

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Rab GTPases in Osteoclastic Bone Resorption and Autophagy.

Roy M, Roux S Int J Mol Sci. 2020; 21(20).

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