Effects of Allogeneic Mesenchymal Stem Cells in a Rat Model of Acute Ischemic Kidney Injury

Overview

Journal Iran J Basic Med Sci

Publisher Mashhad University of Medical Sciences

Specialty General Medicine

Date 2018 Sep 7

PMID 30186570

Citations 8

Authors

Shahrzad Havakhah

Mojtaba Sankian

Gholam Hosein Kazemzadeh

Keyvan Sadri

Hamid Reza Bidkhori

Hojjat Naderi-Meshkin

Alireza Ebrahimzadeh Bideskan

Saeed Niazmand

Ahmad Reza Bahrami

Abolfazl Khajavi Rad

Affiliations

Soon will be listed here.

Abstract

Objectives: Renal ischemia-reperfusion injury (IRI) as a severe condition of acute kidney injury (AKI) is the most common clinical problem with high mortality rates of 35-60% deaths in hospital. Mesenchymal stem cells (MSC) due to unique regenerative characteristics are ideal candidates for the treatment of the ischemic injuries. This work is focused on the administration of MSC to IRI-induced AKI Wistar rats and evaluating their significance in AKI treatment.

Material And Methods: Animals underwent surgical procedure and AKI was induced by 40 min bilateral renal pedicle clamping. Immediately after reperfusion, 2×106 rat bone marrow derived MSCs were injected via intra-parenchymal or intra-aortic route.

Results: Animals subjected to AKI after days 1 and 3 showed significant increase in the serum creatinine and blood urea nitrogen (BUN) concentration along with a declined glomerular filtration rate (GFR) when compared with non-ischemic animals. On the other hand, treated animals showed a significant enhanced regeneration as compared to ischemic animals in both administration route groups.

Conclusion: According to the results concluded from the renoprotective effects of MSC in IRI/AKI, MSCs could be considered as promising therapeutic approach for AKI in clinical applications.

Citing Articles

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Effects of grape seed-derived proanthocyanidin B2 pretreatment on oxidative stress, endoplasmic reticulum stress and apoptosis of renal tubular epithelial cells in renal ischemia-reperfusion injury model of mice.

Wang Z, Shu B, Han Q, Li G, Guo Y Int Urol Nephrol. 2023; 55(10):2599-2610.

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Mesenchymal stem cells versus their conditioned medium in the treatment of ischemia/reperfusion injury: Evaluation of efficacy and hepatic specific gene expression in mice.

Khosravi-Farsani S, Zaminy A, Kazemi S, Hashemzadeh-Chaleshtori M Iran J Basic Med Sci. 2022; 25(7):799-807.

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Mamillapalli R, Cho S, Mutlu L, Taylor H Stem Cell Res Ther. 2022; 13(1):107.

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Therapeutic Effects of Stem Cells From Different Source on Renal Ischemia- Reperfusion Injury: A Systematic Review and Network Meta-analysis of Animal Studies.

Shang Z, Jiang Y, Guan X, Wang A, Ma B Front Pharmacol. 2021; 12:713059.

PMID: 34539400 PMC: 8444551. DOI: 10.3389/fphar.2021.713059.

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