Small Bowel Adenocarcinoma

Overview

Journal Clin Colon Rectal Surg

Date 2018 Sep 7

PMID 30186048

Citations 9

Authors

Emerson Y Chen

Gina M Vaccaro

Affiliations

Soon will be listed here.

Abstract

Small bowel adenocarcinoma is a clinically and anatomically distinct gastrointestinal cancer that lacks prospective data to support its optimal management. Patients with inflammatory bowel disease and inherited conditions that cause gastrointestinal polyps are at especially high risk. Due to a lack of effective surveillance programs resulting in missed or delayed diagnoses only when symptoms develop, this disease is generally discovered at an advanced stage. Surgical resection is the only treatment modality with a chance of cure. Currently accepted treatment considerations are often generalized from large bowel and pancreatic-biliary cancers, due to some anatomic and clinical parallels. Additional research, however, is desperately needed to characterize the unique molecular differences of this disease to better prognosticate patients and establish rational clinical trials that would improve their outcomes.

Citing Articles

Primitive Resectable Small Bowel Cancer Clinical-Pathological Analysis: A 10-Year Retrospective Study in a General Surgery Unit.

Obleaga C, Streba C, Mirea C, Vilcea I, Florescu D, Ciorbagiu M Cancers (Basel). 2024; 16(21).

PMID: 39518149 PMC: 11545816. DOI: 10.3390/cancers16213713.

Bibliometrics analysis on the research status and trends of small bowel adenocarcinoma: 1923-2023.

Lu Y, Pan C, Hu X, Sun J Front Oncol. 2024; 14:1407315.

PMID: 39234397 PMC: 11371555. DOI: 10.3389/fonc.2024.1407315.

Enhancing treatment strategies for small bowel cancer: a clinical review of targeted therapy and immunotherapy approaches.

Ebrahimpour M, Hosseinzadeh H, Abedi F, Nodeh M, Allahyari A, Sahebkar A Naunyn Schmiedebergs Arch Pharmacol. 2024; 397(7):4601-4614.

PMID: 38329524 DOI: 10.1007/s00210-024-02992-1.

Colo-colic intussusception in an adult caused by lipoma: Case report of a rare condition.

Di Stefano C, Salvatori E, Savino L, Forte V, Paoletti S, Ricciardi F Radiol Case Rep. 2023; 19(2):665-670.

PMID: 38111559 PMC: 10726323. DOI: 10.1016/j.radcr.2023.10.080.

Exploring the immune microenvironment in small bowel adenocarcinoma using digital image analysis.

Sidi F, Bingham V, McQuaid S, Craig S, Turkington R, James J PLoS One. 2023; 18(8):e0289355.

PMID: 37527282 PMC: 10393147. DOI: 10.1371/journal.pone.0289355.

References

Sellner F . Investigations on the significance of the adenoma-carcinoma sequence in the small bowel. Cancer. 1990; 66(4):702-15. DOI: 10.1002/1097-0142(19900815)66:4<702::aid-cncr2820660419>3.0.co;2-z. View

Dabaja B, Suki D, Pro B, Bonnen M, Ajani J . Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients. Cancer. 2004; 101(3):518-26. DOI: 10.1002/cncr.20404. View

Rashid A, Hamilton S . Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine. Gastroenterology. 1997; 113(1):127-35. DOI: 10.1016/s0016-5085(97)70087-8. View

Syngal S, Brand R, Church J, Giardiello F, Hampel H, Burt R . ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes. Am J Gastroenterol. 2015; 110(2):223-62. PMC: 4695986. DOI: 10.1038/ajg.2014.435. View

Liu Y, Ishibashi H, Takeshita K, Mizumoto A, Hirano M, Sako S . Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Dissemination from Small Bowel Malignancy: Results from a Single Specialized Center. Ann Surg Oncol. 2016; 23(5):1625-31. DOI: 10.1245/s10434-015-5056-4. View

Wang Y, Jiang C, Guan J, Yang G, Yue J, Chen H . Molecular alterations of EGFR in small intestinal adenocarcinoma. Int J Colorectal Dis. 2013; 28(10):1329-35. DOI: 10.1007/s00384-013-1689-6. View

Overman M, Kopetz S, Wen S, Hoff P, Fogelman D, Morris J . Chemotherapy with 5-fluorouracil and a platinum compound improves outcomes in metastatic small bowel adenocarcinoma. Cancer. 2008; 113(8):2038-45. DOI: 10.1002/cncr.23822. View

Young J, Mongoue-Tchokote S, Wieghard N, Mori M, Vaccaro G, Sheppard B . Treatment and Survival of Small-bowel Adenocarcinoma in the United States: A Comparison With Colon Cancer. Dis Colon Rectum. 2016; 59(4):306-15. DOI: 10.1097/DCR.0000000000000562. View

Haanstra J, Al-Toma A, Dekker E, Vanhoutvin S, Nagengast F, Mathus-Vliegen E . Prevalence of small-bowel neoplasia in Lynch syndrome assessed by video capsule endoscopy. Gut. 2014; 64(10):1578-83. DOI: 10.1136/gutjnl-2014-307348. View

10.

Overman M, Pozadzides J, Kopetz S, Wen S, Abbruzzese J, Wolff R . Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. Br J Cancer. 2009; 102(1):144-50. PMC: 2813754. DOI: 10.1038/sj.bjc.6605449. View

11.

Blaker H, von Herbay A, Penzel R, Gross S, Otto H . Genetics of adenocarcinomas of the small intestine: frequent deletions at chromosome 18q and mutations of the SMAD4 gene. Oncogene. 2002; 21(1):158-64. DOI: 10.1038/sj.onc.1205041. View

12.

Koo D, Yun S, Hong Y, Ryu M, Lee J, Chang H . Adjuvant chemotherapy for small bowel adenocarcinoma after curative surgery. Oncology. 2011; 80(3-4):208-13. DOI: 10.1159/000328506. View

13.

Legue L, Bernards N, Gerritse S, van Oudheusden T, de Hingh I, Creemers G . Trends in incidence, treatment and survival of small bowel adenocarcinomas between 1999 and 2013: a population-based study in The Netherlands. Acta Oncol. 2016; 55(9-10):1183-1189. DOI: 10.1080/0284186X.2016.1182211. View

14.

Laforest A, Aparicio T, Zaanan A, Silva F, Didelot A, Desbeaux A . ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma. Eur J Cancer. 2014; 50(10):1740-1746. DOI: 10.1016/j.ejca.2014.04.007. View

15.

Czaykowski P, Hui D . Chemotherapy in small bowel adenocarcinoma: 10-year experience of the British Columbia Cancer Agency. Clin Oncol (R Coll Radiol). 2007; 19(2):143-9. DOI: 10.1016/j.clon.2006.12.001. View

16.

Alvi M, McArt D, Kelly P, Fuchs M, Alderdice M, McCabe C . Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility. Oncotarget. 2015; 6(25):20863-74. PMC: 4673235. DOI: 10.18632/oncotarget.4576. View

17.

Arber N, Hibshoosh H, Yasui W, Neugut A, Hibshoosh A, Yao Y . Abnormalities in the expression of cell cycle-related proteins in tumors of the small bowel. Cancer Epidemiol Biomarkers Prev. 1999; 8(12):1101-5. View

18.

Overman M, Varadhachary G, Kopetz S, Adinin R, Lin E, Morris J . Phase II study of capecitabine and oxaliplatin for advanced adenocarcinoma of the small bowel and ampulla of Vater. J Clin Oncol. 2009; 27(16):2598-603. DOI: 10.1200/JCO.2008.19.7145. View

19.

Hampel H, de la Chapelle A . The search for unaffected individuals with Lynch syndrome: do the ends justify the means?. Cancer Prev Res (Phila). 2011; 4(1):1-5. PMC: 3076593. DOI: 10.1158/1940-6207.CAPR-10-0345. View

20.

Zaaimi Y, Aparicio T, Laurent-Puig P, Taieb J, Zaanan A . Advanced small bowel adenocarcinoma: Molecular characteristics and therapeutic perspectives. Clin Res Hepatol Gastroenterol. 2015; 40(2):154-60. DOI: 10.1016/j.clinre.2015.09.008. View