Effect of Duration of Diabetes on Bone Mineral Density: a Population Study on East Asian Males

Overview

Journal BMC Endocr Disord

Publisher Biomed Central

Specialty Endocrinology

Date 2018 Sep 7

PMID 30185190

Citations 13

Authors

Miso Jang

Hyunkyung Kim

Shorry Lea

Sohee Oh

Jong Seung Kim

Bumjo Oh

Affiliations

Soon will be listed here.

Abstract

Background: The aim of the present study is to evaluate the association between BMD and type 2 DM status in middle-aged and elderly men. To investigate a possible correlation, the present study used the BMD dataset of the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011.

Methods: In total, 37,753 individuals participated in health examination surveys between 2008 and 2011. A total of 3383 males aged ≥50 years were eligible. They underwent BMD measurement through dual-energy X-ray absorptiometry (DXA). The fasting plasma glucose and insulin levels of participants were also measured.

Results: Men with prediabetes and diabetes had significantly higher mean BMD at all measured sites than control men did, irrespective of DM status. This was confirmed by multivariable linear regression analyses. DM duration was an important factor affecting BMD. Patients with DM for > 5 years had lower mean BMD in the total hip and femoral neck than those with DM for ≤5 years. Per multivariable linear regression analyses, patients with DM for > 5 years had significantly lower mean BMD at the femoral neck than those with DM ≤5 years.

Conclusions: DM duration was significantly associated with reduced femoral neck BMD.

Citing Articles

Risk factors for osteoporosis in elderly patients with type 2 diabetes: A protocol for systematic review and meta-analysis.

Su W, Jia H, Yang L, Zhang J, Wei Z, Tsikwa P PLoS One. 2025; 20(2):e0319602.

PMID: 40014597 PMC: 11867315. DOI: 10.1371/journal.pone.0319602.

Correlation Between Blood Glucose Fluctuations and Osteoporosis in Type 2 Diabetes Mellitus.

Chen F, Wang P, Dai F, Zhang Q, Ying R, Ai L Int J Endocrinol. 2025; 2025:8889420.

PMID: 39949568 PMC: 11824305. DOI: 10.1155/ije/8889420.

Mendelian randomization studies of risk and protective factors for osteoporosis: a systematic review and meta-analysis.

Ji W, Pan B, Chen X, Lao Z, Yang W, Qian Y Front Endocrinol (Lausanne). 2025; 15:1486188.

PMID: 39886030 PMC: 11779621. DOI: 10.3389/fendo.2024.1486188.

Prevalence of Osteoporosis and Osteopenia in Patients With Type 2 Diabetes at King Abdulaziz University Hospital: A Retrospective Analysis.

Bassi M, Halawani I, Alshehri H, Alyahya F, Alhindi M, Alamri R Cureus. 2025; 17(1):e77624.

PMID: 39834664 PMC: 11743528. DOI: 10.7759/cureus.77624.

Insulin resistance, bone health, and fracture risk.

Armutcu F, McCloskey E Osteoporos Int. 2024; 35(11):1909-1917.

PMID: 39264439 DOI: 10.1007/s00198-024-07227-w.

References

Schwartz A, Vittinghoff E, Bauer D, Hillier T, Strotmeyer E, Ensrud K . Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. JAMA. 2011; 305(21):2184-92. PMC: 3287389. DOI: 10.1001/jama.2011.715. View

Morimoto A, Tatsumi Y, Deura K, Mizuno S, Ohno Y, Miyamatsu N . Impact of impaired insulin secretion and insulin resistance on the incidence of type 2 diabetes mellitus in a Japanese population: the Saku study. Diabetologia. 2013; 56(8):1671-9. DOI: 10.1007/s00125-013-2932-y. View

Yoon K, Lee J, Kim J, Cho J, Choi Y, Ko S . Epidemic obesity and type 2 diabetes in Asia. Lancet. 2006; 368(9548):1681-8. DOI: 10.1016/S0140-6736(06)69703-1. View

Ma L, Oei L, Jiang L, Estrada K, Chen H, Wang Z . Association between bone mineral density and type 2 diabetes mellitus: a meta-analysis of observational studies. Eur J Epidemiol. 2012; 27(5):319-32. PMC: 3374119. DOI: 10.1007/s10654-012-9674-x. View

Vestergaard P . Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes--a meta-analysis. Osteoporos Int. 2006; 18(4):427-44. DOI: 10.1007/s00198-006-0253-4. View

Majumdar S, Leslie W, Lix L, Morin S, Johansson H, Oden A . Longer Duration of Diabetes Strongly Impacts Fracture Risk Assessment: The Manitoba BMD Cohort. J Clin Endocrinol Metab. 2016; 101(11):4489-4496. PMC: 5095256. DOI: 10.1210/jc.2016-2569. View

Leslie W, Aubry-Rozier B, Lamy O, Hans D . TBS (trabecular bone score) and diabetes-related fracture risk. J Clin Endocrinol Metab. 2013; 98(2):602-9. DOI: 10.1210/jc.2012-3118. View

Kweon S, Kim Y, Jang M, Kim Y, Kim K, Choi S . Data resource profile: the Korea National Health and Nutrition Examination Survey (KNHANES). Int J Epidemiol. 2014; 43(1):69-77. PMC: 3937975. DOI: 10.1093/ije/dyt228. View

Johnell O, Kanis J . An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006; 17(12):1726-33. DOI: 10.1007/s00198-006-0172-4. View

10.

Leidig-Bruckner G, Grobholz S, Bruckner T, Scheidt-Nave C, Nawroth P, Schneider J . Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus. BMC Endocr Disord. 2014; 14:33. PMC: 4021186. DOI: 10.1186/1472-6823-14-33. View

11.

Heilmeier U, Carpenter D, Patsch J, Harnish R, Joseph G, Burghardt A . Volumetric femoral BMD, bone geometry, and serum sclerostin levels differ between type 2 diabetic postmenopausal women with and without fragility fractures. Osteoporos Int. 2015; 26(4):1283-93. DOI: 10.1007/s00198-014-2988-7. View

12.

Shin D, Kim S, Kim K, Lee K, Park S . Association between insulin resistance and bone mass in men. J Clin Endocrinol Metab. 2014; 99(3):988-95. DOI: 10.1210/jc.2013-3338. View

13.

Thrailkill K, Lumpkin Jr C, Bunn R, Kemp S, Fowlkes J . Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab. 2005; 289(5):E735-45. PMC: 2387001. DOI: 10.1152/ajpendo.00159.2005. View

14.

de Liefde I, van der Klift M, de Laet C, van Daele P, Hofman A, Pols H . Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study. Osteoporos Int. 2005; 16(12):1713-20. DOI: 10.1007/s00198-005-1909-1. View

15.

Napoli N, Chandran M, Pierroz D, Abrahamsen B, Schwartz A, Ferrari S . Mechanisms of diabetes mellitus-induced bone fragility. Nat Rev Endocrinol. 2016; 13(4):208-219. DOI: 10.1038/nrendo.2016.153. View

16.

Kim Y, Kim J, Cho D . [Gender difference in osteoporosis prevalence, awareness and treatment: based on the Korea national health and nutrition examination survey 2008~2011]. J Korean Acad Nurs. 2015; 45(2):293-305. DOI: 10.4040/jkan.2015.45.2.293. View

17.

Ohn J, Kwak S, Cho Y, Lim S, Jang H, Park K . 10-year trajectory of β-cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study. Lancet Diabetes Endocrinol. 2015; 4(1):27-34. DOI: 10.1016/S2213-8587(15)00336-8. View

18.

Dennison E, Syddall H, Aihie Sayer A, Craighead S, Phillips D, Cooper C . Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance?. Diabetologia. 2004; 47(11):1963-8. DOI: 10.1007/s00125-004-1560-y. View

19.

Napoli N, Strollo R, Paladini A, Briganti S, Pozzilli P, Epstein S . The alliance of mesenchymal stem cells, bone, and diabetes. Int J Endocrinol. 2014; 2014:690783. PMC: 4124651. DOI: 10.1155/2014/690783. View

20.

FRIEDEWALD W, Levy R, Fredrickson D . Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6):499-502. View