Regulatory T Cells and Asthma

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2018 Sep 5

PMID 30178633

Citations 44

Authors

Sheng-Tao Zhao

Chang-Zheng Wang

Affiliations

Soon will be listed here.

Abstract

Asthma is a chronic disease of airway inflammation due to excessive T helper cell type 2 (Th2) response. Present treatment based on inhalation of synthetic glucocorticoids can only control Th2-driven chronic eosinophilic inflammation, but cannot change the immune tolerance of the body to external allergens. Regulatory T cells (Tregs) are the main negative regulatory cells of the immune response. Tregs play a great role in regulating allergic, autoimmune, graft-versus-host responses, and other immune responses. In this review, we will discuss the classification and biological characteristics, the established immunomodulatory mechanisms, and the characteristics of induced differentiation of Tregs. We will also discuss the progress of Tregs in the field of asthma. We believe that further studies on the regulatory mechanisms of Tregs will provide better treatments and control strategies for asthma.

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References

Massoud A, Charbonnier L, Lopez D, Pellegrini M, Phipatanakul W, Chatila T . An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells. Nat Med. 2016; 22(9):1013-22. PMC: 5014738. DOI: 10.1038/nm.4147. View

Tachdjian R, Mathias C, Al Khatib S, Bryce P, Kim H, Blaeser F . Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med. 2009; 206(10):2191-204. PMC: 2757875. DOI: 10.1084/jem.20091480. View

Round J, Mazmanian S . Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010; 107(27):12204-9. PMC: 2901479. DOI: 10.1073/pnas.0909122107. View

Deaglio S, Robson S . Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity. Adv Pharmacol. 2011; 61:301-32. PMC: 5879773. DOI: 10.1016/B978-0-12-385526-8.00010-2. View

Jethwa H, Adami A, Maher J . Use of gene-modified regulatory T-cells to control autoimmune and alloimmune pathology: is now the right time?. Clin Immunol. 2013; 150(1):51-63. DOI: 10.1016/j.clim.2013.11.004. View

Sagoo P, Ali N, Garg G, Nestle F, Lechler R, Lombardi G . Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells. Sci Transl Med. 2011; 3(83):83ra42. PMC: 3776382. DOI: 10.1126/scitranslmed.3002076. View

Komatsu N, Mariotti-Ferrandiz M, Wang Y, Malissen B, Waldmann H, Hori S . Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A. 2009; 106(6):1903-8. PMC: 2644136. DOI: 10.1073/pnas.0811556106. View

Krishnamoorthy N, Khare A, Oriss T, Raundhal M, Morse C, Yarlagadda M . Early infection with respiratory syncytial virus impairs regulatory T cell function and increases susceptibility to allergic asthma. Nat Med. 2012; 18(10):1525-30. PMC: 3641779. DOI: 10.1038/nm.2896. View

Sitkovsky M, Lukashev D, Deaglio S, Dwyer K, Robson S, Ohta A . Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells. Br J Pharmacol. 2008; 153 Suppl 1:S457-64. PMC: 2268051. DOI: 10.1038/bjp.2008.23. View

10.

Lapierre P, Beland K, Yang R, Alvarez F . Adoptive transfer of ex vivo expanded regulatory T cells in an autoimmune hepatitis murine model restores peripheral tolerance. Hepatology. 2012; 57(1):217-27. DOI: 10.1002/hep.26023. View

11.

Hartl D, Koller B, Mehlhorn A, Reinhardt D, Nicolai T, Schendel D . Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma. J Allergy Clin Immunol. 2007; 119(5):1258-66. DOI: 10.1016/j.jaci.2007.02.023. View

12.

Wills-Karp M, Santeliz J, Karp C . The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol. 2002; 1(1):69-75. DOI: 10.1038/35095579. View

13.

Stelmach I, Sobocinska A, Majak P, Smejda K, Jerzynska J, Stelmach W . Comparison of the long-term efficacy of 3- and 5-year house dust mite allergen immunotherapy. Ann Allergy Asthma Immunol. 2012; 109(4):274-8. DOI: 10.1016/j.anai.2012.07.015. View

14.

Ohnmacht C, Park J, Cording S, Wing J, Atarashi K, Obata Y . MUCOSAL IMMUNOLOGY. The microbiota regulates type 2 immunity through RORγt⁺ T cells. Science. 2015; 349(6251):989-93. DOI: 10.1126/science.aac4263. View

15.

Joetham A, Schedel M, OConnor B, Kim S, Takeda K, Abbott J . Inducible and naturally occurring regulatory T cells enhance lung allergic responses through divergent transcriptional pathways. J Allergy Clin Immunol. 2016; 139(4):1331-1342. PMC: 5313386. DOI: 10.1016/j.jaci.2016.06.051. View

16.

Zimmermann N, Bernstein J, Rothenberg M, Khurana Hershey G . The R576 IL-4 receptor alpha allele correlates with asthma severity. J Allergy Clin Immunol. 1999; 104(5):1008-14. DOI: 10.1016/s0091-6749(99)70082-5. View

17.

Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-Hora M, Kodama T . Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med. 2013; 20(1):62-8. DOI: 10.1038/nm.3432. View

18.

Rudensky A . Regulatory T cells and Foxp3. Immunol Rev. 2011; 241(1):260-8. PMC: 3077798. DOI: 10.1111/j.1600-065X.2011.01018.x. View

19.

Read S, Malmstrom V, Powrie F . Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med. 2000; 192(2):295-302. PMC: 2193261. DOI: 10.1084/jem.192.2.295. View

20.

Collison L, Workman C, Kuo T, Boyd K, Wang Y, Vignali K . The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature. 2007; 450(7169):566-9. DOI: 10.1038/nature06306. View