The Association Between MMP-1 Gene Rs1799750 Polymorphism and Knee Osteoarthritis Risk

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2018 Sep 5

PMID 30177524

Citations 12

Authors

Rui Geng

Yuansheng Xu

Wenhao Hu

Hui Zhao

Affiliations

Soon will be listed here.

Abstract

Matrix metalloproteinase 1 (MMP-1) degrades cartilage, which may result in osteoarthritis (OA) development. Several studies have explored the association between gene rs1799750 polymorphism and OA in different populations. However, the results are inconsistent. The aim of this case-control study was to investigate the association between MMP-1 gene rs1799750 polymorphism and knee OA in a Chinese population. The present study included 308 cases and 404 controls. Genotyping was performed using standard polymerase chain reaction and restriction fragment length polymorphism. The present study found that 2G2G genotype (2G2G vs 1G1G: OR & 95% CI, 2.28 (1.47-3.53), <0.001; 2G2G + 1G2G vs 1G1G: OR & 95% CI, 1.61 (1.15-2.24), =0.005; 2G2G vs 1G2G + 1G1G: OR & 95% CI, 1.84 (1.26-2.68), =0.002) or 2G allele carriers (2G vs 1G: OR & 95% CI, 1.48 (1.20-1.83), <0.001) of gene rs1799750 polymorphism increased the risk of OA. In conclusion, this case-control study confirms that gene rs1799750 polymorphism increases the risk of knee OA in Chinese Han population.

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