Coatings As the Useful Drug Delivery System for the Prevention of Implant-related Infections

Overview

Journal J Orthop Surg Res

Publisher Biomed Central

Specialty Orthopedics

Date 2018 Sep 5

PMID 30176886

Citations 31

Authors

Chenhao Pan

Zubin Zhou

Xiaowei Yu

Affiliations

Soon will be listed here.

Abstract

Implant-related infections (IRIs) which led to a large amount of medical expenditure were caused by bacteria and fungi that involve the implants in the operation or in ward. Traditional treatments of IRIs were comprised of repeated radical debridement, replacement of internal fixators, and intravenous antibiotics. It needed a long time and numbers of surgeries to cure, which meant a catastrophe to patients. So how to prevent it was more important than to cure it. As an excellent local release system, coating is a good idea by its local drug infusion and barrier effect on resisting biofilms which were the main cause of IRIs. So in this review, materials used for coatings and evidences of prevention were elaborated.

Citing Articles

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References

Liu P, Zhao Y, Yuan Z, Ding H, Hu Y, Yang W . Construction of Zn-incorporated multilayer films to promote osteoblasts growth and reduce bacterial adhesion. Mater Sci Eng C Mater Biol Appl. 2017; 75:998-1005. DOI: 10.1016/j.msec.2017.03.020. View

Albrektsson T, Wennerberg A . Oral implant surfaces: Part 1--review focusing on topographic and chemical properties of different surfaces and in vivo responses to them. Int J Prosthodont. 2004; 17(5):536-43. View

Rabea E, Badawy M, Stevens C, Smagghe G, Steurbaut W . Chitosan as antimicrobial agent: applications and mode of action. Biomacromolecules. 2003; 4(6):1457-65. DOI: 10.1021/bm034130m. View

Lovati A, Bottagisio M, De Vecchi E, Gallazzi E, Drago L . Animal Models of Implant-Related Low-Grade Infections. A Twenty-Year Review. Adv Exp Med Biol. 2016; 971:29-50. DOI: 10.1007/5584_2016_157. View

Cataldo M, Petrosillo N, Cipriani M, Cauda R, Tacconelli E . Prosthetic joint infection: recent developments in diagnosis and management. J Infect. 2010; 61(6):443-8. DOI: 10.1016/j.jinf.2010.09.033. View

Hashemi Doulabi A, Mirzadeh H, Imani M, Samadi N . Chitosan/polyethylene glycol fumarate blend film: physical and antibacterial properties. Carbohydr Polym. 2012; 92(1):48-56. DOI: 10.1016/j.carbpol.2012.09.002. View

Bai X, Sandukas S, Appleford M, Ong J, Rabiei A . Antibacterial effect and cytotoxicity of Ag-doped functionally graded hydroxyapatite coatings. J Biomed Mater Res B Appl Biomater. 2011; 100(2):553-61. DOI: 10.1002/jbm.b.31985. View

Wei Q, Becherer T, Angioletti-Uberti S, Dzubiella J, Wischke C, Neffe A . Protein interactions with polymer coatings and biomaterials. Angew Chem Int Ed Engl. 2014; 53(31):8004-31. DOI: 10.1002/anie.201400546. View

Pulido L, Ghanem E, Joshi A, Purtill J, Parvizi J . Periprosthetic joint infection: the incidence, timing, and predisposing factors. Clin Orthop Relat Res. 2008; 466(7):1710-5. PMC: 2505241. DOI: 10.1007/s11999-008-0209-4. View

10.

Uskokovic V, Desai T . In vitro analysis of nanoparticulate hydroxyapatite/chitosan composites as potential drug delivery platforms for the sustained release of antibiotics in the treatment of osteomyelitis. J Pharm Sci. 2014; 103(2):567-79. PMC: 4045008. DOI: 10.1002/jps.23824. View

11.

Raschke M, Vordemvenne T, Fuchs T . Limb salvage or amputation? The use of a gentamicin coated nail in a severe, grade IIIc tibia fracture. Eur J Trauma Emerg Surg. 2016; 36(6):605-8. DOI: 10.1007/s00068-010-0017-x. View

12.

Windolf C, Logters T, Scholz M, Windolf J, Flohe S . Lysostaphin-coated titan-implants preventing localized osteitis by Staphylococcus aureus in a mouse model. PLoS One. 2014; 9(12):e115940. PMC: 4275259. DOI: 10.1371/journal.pone.0115940. View

13.

Ren W, Muzik O, Jackson N, Khoury B, Shi T, Flynn J . Differentiation of septic and aseptic loosening by PET with both 11C-PK11195 and 18F-FDG in rat models. Nucl Med Commun. 2012; 33(7):747-56. DOI: 10.1097/MNM.0b013e328353bbd3. View

14.

Nishitani K, Sutipornpalangkul W, Bentley K, Varrone J, Bello-Irizarry S, Ito H . Quantifying the natural history of biofilm formation in vivo during the establishment of chronic implant-associated Staphylococcus aureus osteomyelitis in mice to identify critical pathogen and host factors. J Orthop Res. 2015; 33(9):1311-9. PMC: 4529770. DOI: 10.1002/jor.22907. View

15.

Yang C, Lin C, Liao J, Yen S . Vancomycin-chitosan composite deposited on post porous hydroxyapatite coated Ti6Al4V implant for drug controlled release. Mater Sci Eng C Mater Biol Appl. 2013; 33(4):2203-12. DOI: 10.1016/j.msec.2013.01.038. View

16.

Tsuchiya H, Shirai T, Nishida H, Murakami H, Kabata T, Yamamoto N . Innovative antimicrobial coating of titanium implants with iodine. J Orthop Sci. 2012; 17(5):595-604. PMC: 3462916. DOI: 10.1007/s00776-012-0247-3. View

17.

Merghni A, Bekir K, Kadmi Y, Dallel I, Janel S, Bovio S . Adhesiveness of opportunistic Staphylococcus aureus to materials used in dental office: In vitro study. Microb Pathog. 2016; 103:129-134. DOI: 10.1016/j.micpath.2016.12.014. View

18.

Lemire J, Harrison J, Turner R . Antimicrobial activity of metals: mechanisms, molecular targets and applications. Nat Rev Microbiol. 2013; 11(6):371-84. DOI: 10.1038/nrmicro3028. View

19.

Moormeier D, Bayles K . Staphylococcus aureus biofilm: a complex developmental organism. Mol Microbiol. 2017; 104(3):365-376. PMC: 5397344. DOI: 10.1111/mmi.13634. View

20.

Lorenzetti M, Dogsa I, Stosicki T, Stopar D, Kalin M, Kobe S . The influence of surface modification on bacterial adhesion to titanium-based substrates. ACS Appl Mater Interfaces. 2014; 7(3):1644-51. DOI: 10.1021/am507148n. View