Targeting Calpain for Heart Failure Therapy: Implications From Multiple Murine Models

Overview

Journal JACC Basic Transl Sci

Date 2018 Sep 4

PMID 30175274

Citations 33

Authors

Yihui Wang

Biyi Chen

Chun-Kai Huang

Ang Guo

Jennifer Wu

Xiaoming Zhang

Rong Chen

Cheng Chen

William Kutschke

Robert M Weiss

Ryan L Boudreau

Kenneth B Margulies

Jiang Hong

Long-Sheng Song

Affiliations

Soon will be listed here.

Abstract

Heart failure remains a major cause of morbidity and mortality in developed countries. There is still a strong need to devise new mechanism-based treatments for heart failure. Numerous studies have suggested the importance of the Ca-dependent protease calpain in cardiac physiology and pathology. However, no drugs are currently under development or testing in human patients to target calpain for heart failure treatment. Herein the data demonstrate that inhibition of calpain activity protects against deleterious ultrastructural remodeling and cardiac dysfunction in multiple rodent models of heart failure, providing compelling evidence that calpain inhibition is a promising therapeutic strategy for heart failure treatment.

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