Multifractal Analysis Reveals Decreased Non-linearity and Stronger Anticorrelations in Heart Period Fluctuations of Fibromyalgia Patients

Overview

Journal Front Physiol

Date 2018 Sep 4

PMID 30174611

Citations 9

Authors

Cesar F Reyes-Manzano

Claudia Lerma

Juan C Echeverria

Manuel Martinez-Lavin

Laura A Martinez-Martinez

Oscar Infante

Lev Guzman-Vargas

Affiliations

Soon will be listed here.

Abstract

To characterize the multifractal behavior of the beat to beat heart-period or RR fluctuations in fibromyalgia patients (FM) in comparison with healthy-matched subjects. Multifractral detrended fluctuation analysis (MDFA) was used to study multifractality in heartbeat times-series from 30 female healthy subjects and 30 female patients with fibromyalgia during day and night periods.The multifractal changes as derived from the magnitude and sign analysis of these RR fluctuations were also assessed. The RR fluctuations dynamics of healthy subjects showed a broad multifractal spectrum. By contrast, a noticeable decrease in multifractality and non-linearity was observed for patients with fibromyalgia. In addition, the spectra corresponding to FM subjects were located on the average to the right of the spectra of healthy individuals, indicating that the local scaling exponents reflect a smoother behavior compared to healthy dynamics. Moreover, the multifractal analysis as applied to the magnitude and sign heartbeat series confirmed that, in addition to a decreased nonlinearity, fibromyalgia patients presented stronger anticorrelation in directionality, which did not remain invariant for small or rather larger fluctuations as it occurred in healthy subjects. When compared to healthy controls, fibromyalgia patients display decreased nonlinearity and stronger anticorrelations in heart period fluctuations. These findings reinforce the hypothesis of the potential role of the dysfunctional autonomic nervous system in the pathogenesis of fibromyalgia.

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References

Wang J, Shang P, Cui X . Multiscale multifractal analysis of traffic signals to uncover richer structures. Phys Rev E Stat Nonlin Soft Matter Phys. 2014; 89(3):032916. DOI: 10.1103/PhysRevE.89.032916. View

Meeus M, Goubert D, De Backer F, Struyf F, Hermans L, Coppieters I . Heart rate variability in patients with fibromyalgia and patients with chronic fatigue syndrome: a systematic review. Semin Arthritis Rheum. 2013; 43(2):279-87. DOI: 10.1016/j.semarthrit.2013.03.004. View

Ivanov P, Ma Q, Bartsch R, Hausdorff J, Nunes Amaral L, Schulte-Frohlinde V . Levels of complexity in scale-invariant neural signals. Phys Rev E Stat Nonlin Soft Matter Phys. 2009; 79(4 Pt 1):041920. PMC: 6653582. DOI: 10.1103/PhysRevE.79.041920. View

Reyes-Lagos J, Hadamitzky M, Pena-Castillo M, Echeverria J, Bosche K, Luckemann L . Exogenous oxytocin reduces signs of sickness behavior and modifies heart rate fluctuations of endotoxemic rats. Physiol Behav. 2016; 165:223-30. DOI: 10.1016/j.physbeh.2016.07.013. View

Ivanov PCh , Bunde A, Amaral L, Havlin S, Baevsky R, Stanley H . Sleep-wake differences in scaling behavior of the human heartbeat: analysis of terrestrial and long-term space flight data. Europhys Lett. 2001; 48(5):594-600. DOI: 10.1209/epl/i1999-00525-0. View

Schmitt D, Ivanov P . Fractal scale-invariant and nonlinear properties of cardiac dynamics remain stable with advanced age: a new mechanistic picture of cardiac control in healthy elderly. Am J Physiol Regul Integr Comp Physiol. 2007; 293(5):R1923-37. DOI: 10.1152/ajpregu.00372.2007. View

Diatchenko L, Slade G, Nackley A, Bhalang K, Sigurdsson A, Belfer I . Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet. 2004; 14(1):135-43. DOI: 10.1093/hmg/ddi013. View

Lerma C, Martinez-Martinez L, Ruiz N, Vargas A, Infante O, Martinez-Lavin M . Fibromyalgia beyond reductionism. Heart rhythm fractal analysis to assess autonomic nervous system resilience. Scand J Rheumatol. 2015; 45(2):151-7. DOI: 10.3109/03009742.2015.1055299. View

Sergi M, Rizzi M, Braghiroli A, Sarzi Puttini P, Greco M, Cazzola M . Periodic breathing during sleep in patients affected by fibromyalgia syndrome. Eur Respir J. 1999; 14(1):203-8. DOI: 10.1034/j.1399-3003.1999.14a34.x. View

10.

Ivanov PCh , Nunes Amaral L, Goldberger A, Stanley H . Stochastic feedback and the regulation of biological rhythms. Europhys Lett. 2001; 43(4):363-8. DOI: 10.1209/epl/i1998-00366-3. View

11.

Ivanov P, Rosenblum M, Peng C, Mietus J, Havlin S, Stanley H . Scaling behaviour of heartbeat intervals obtained by wavelet-based time-series analysis. Nature. 1996; 383(6598):323-7. DOI: 10.1038/383323a0. View

12.

Nunes Amaral L, Ivanov P, Aoyagi N, Hidaka I, Tomono S, Goldberger A . Behavioral-independent features of complex heartbeat dynamics. Phys Rev Lett. 2001; 86(26 Pt 1):6026-9. DOI: 10.1103/PhysRevLett.86.6026. View

13.

Martinez-Lavin M, Infante O, Lerma C . Hypothesis: the chaos and complexity theory may help our understanding of fibromyalgia and similar maladies. Semin Arthritis Rheum. 2007; 37(4):260-4. DOI: 10.1016/j.semarthrit.2007.04.003. View

14.

Martinez-Lavin M . Fibromyalgia as a sympathetically maintained pain syndrome. Curr Pain Headache Rep. 2004; 8(5):385-9. DOI: 10.1007/s11916-996-0012-4. View

15.

Martinez-Lavin M, Hermosillo A, Rosas M, Soto M . Circadian studies of autonomic nervous balance in patients with fibromyalgia: a heart rate variability analysis. Arthritis Rheum. 1998; 41(11):1966-71. DOI: 10.1002/1529-0131(199811)41:11<1966::AID-ART11>3.0.CO;2-O. View

16.

Goldberger A, Amaral L, Hausdorff J, Ivanov P, Peng C, Stanley H . Fractal dynamics in physiology: alterations with disease and aging. Proc Natl Acad Sci U S A. 2002; 99 Suppl 1:2466-72. PMC: 128562. DOI: 10.1073/pnas.012579499. View

17.

Peng C, Buldyrev S, Havlin S, Simons M, Stanley H, Goldberger A . Mosaic organization of DNA nucleotides. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1994; 49(2):1685-9. DOI: 10.1103/physreve.49.1685. View

18.

Arneodo , Bacry , Graves , Muzy . Characterizing long-range correlations in DNA sequences from wavelet analysis. Phys Rev Lett. 1995; 74(16):3293-3296. DOI: 10.1103/PhysRevLett.74.3293. View

19.

Pena M, Echeverria J, Garcia M, Gonzalez-Camarena R . Applying fractal analysis to short sets of heart rate variability data. Med Biol Eng Comput. 2009; 47(7):709-17. DOI: 10.1007/s11517-009-0436-1. View

20.

Galaska R, Makowiec D, Dudkowska A, Koprowski A, Chlebus K, Wdowczyk-Szulc J . Comparison of wavelet transform modulus maxima and multifractal detrended fluctuation analysis of heart rate in patients with systolic dysfunction of left ventricle. Ann Noninvasive Electrocardiol. 2008; 13(2):155-64. PMC: 6932668. DOI: 10.1111/j.1542-474X.2008.00215.x. View