Study of Uridine Effect on the Development of Audiogenic Tonic Seizures in Krushinsky-Molodkina Strain Rats

Overview

Journal Dokl Biol Sci

Specialty Biology

Date 2018 Sep 2

PMID 30171462

Authors

I B Fedotova

G M Nikolaev

O V Perepelkina

N V Belosludtseva

G D Mironova

I I Poletaeva

Affiliations

Soon will be listed here.

Abstract

The latency of tonic seizure in response to loud sound (in rats of the Krushinsky-Molodkina strain with audiogenic epilepsy) had been slightly (although statistically significantly) longer after chronic uridine injections (100 mg/kg, i.p., three times a day during 9 or 12 days). The recovery time from the tonic seizure was shorter after 12 days of injections in comparison to the 9-day injection period. At the same time, the intensity of tonic seizures provoked by loud sound did not change after chronic uridine injections. The lack of uridine anticonvulsive effect demonstrated in the audiogenic epilepsy model contradicts the anticonvulsant effects of uridine in experiments with other seizure models, in which the epileptic foci were localized in the forebrain structures.

References

Faingold C, Randall M . Pontine reticular formation neurons exhibit a premature and precipitous increase in acoustic responses prior to audiogenic seizures in genetically epilepsy-prone rats. Brain Res. 1995; 704(2):218-26. DOI: 10.1016/0006-8993(95)01116-1. View

Garcia-Cairasco N . A critical review on the participation of inferior colliculus in acoustic-motor and acoustic-limbic networks involved in the expression of acute and kindled audiogenic seizures. Hear Res. 2002; 168(1-2):208-22. DOI: 10.1016/s0378-5955(02)00371-4. View

Kwan P, Schachter S, Brodie M . Drug-resistant epilepsy. N Engl J Med. 2011; 365(10):919-26. DOI: 10.1056/NEJMra1004418. View

Venediktova N, Gorbacheva O, Belosludtseva N, Fedotova I, Surina N, Poletaeva I . Energetic, oxidative and ionic exchange in rat brain and liver mitochondria at experimental audiogenic epilepsy (Krushinsky-Molodkina model). J Bioenerg Biomembr. 2017; 49(2):149-158. DOI: 10.1007/s10863-016-9693-5. View

Ferranti R, da Silva M, Kowaltowski A . Mitochondrial ATP-sensitive K+ channel opening decreases reactive oxygen species generation. FEBS Lett. 2003; 536(1-3):51-5. DOI: 10.1016/s0014-5793(03)00007-3. View

Poletaeva I, Surina N, Kostina Z, Perepelkina O, Fedotova I . The Krushinsky-Molodkina rat strain: The study of audiogenic epilepsy for 65years. Epilepsy Behav. 2015; 71(Pt B):130-141. DOI: 10.1016/j.yebeh.2015.04.072. View

Zhao Q, Marolewski A, Rusche J, Holmes G . Effects of uridine in models of epileptogenesis and seizures. Epilepsy Res. 2006; 70(1):73-82. DOI: 10.1016/j.eplepsyres.2006.03.003. View

Loscher W . Mechanisms of drug resistance. Epileptic Disord. 2005; 7 Suppl 1:S3-9. View

Faingold C . Neuronal networks in the genetically epilepsy-prone rat. Adv Neurol. 1999; 79:311-21. View

10.

Mironova G, Kachaeva E, Kopylov A . [Mitochondrial ATP-dependent potassium channel. 1. The structure of the channel, the mechanisms of its functioning and regulation]. Vestn Ross Akad Med Nauk. 2007; (2):34-43. View

11.

Kovacs Z, Slezia A, Bali Z, Kovacs P, Dobolyi A, Szikra T . Uridine modulates neuronal activity and inhibits spike-wave discharges of absence epileptic Long Evans and Wistar Albino Glaxo/Rijswijk rats. Brain Res Bull. 2013; 97:16-23. DOI: 10.1016/j.brainresbull.2013.05.009. View

12.

Mironova G, Negoda A, Marinov B, Paucek P, Costa A, Grigoriev S . Functional distinctions between the mitochondrial ATP-dependent K+ channel (mitoKATP) and its inward rectifier subunit (mitoKIR). J Biol Chem. 2004; 279(31):32562-8. DOI: 10.1074/jbc.M401115200. View

13.

Kovacs Z, Kekesi K, Juhasz G, Barna J, Heja L, Lakatos R . Non-adenosine nucleoside inosine, guanosine and uridine as promising antiepileptic drugs: a summary of current literature. Mini Rev Med Chem. 2014; 14(13):1033-42. DOI: 10.2174/1389557514666141107120226. View