A Cell-Enriched Engineered Myocardial Graft Limits Infarct Size and Improves Cardiac Function: Pre-Clinical Study in the Porcine Myocardial Infarction Model

Overview

Journal JACC Basic Transl Sci

Date 2018 Sep 1

PMID 30167524

Citations 17

Authors

Isaac Perea-Gil

Cristina Prat-Vidal

Carolina Galvez-Monton

Santiago Roura

Aida Llucia-Valldeperas

Carolina Soler-Botija

Oriol Iborra-Egea

Idoia Diaz-Guemes

Veronica Crisostomo

Francisco M Sanchez-Margallo

Antoni Bayes-Genis

Affiliations

Soon will be listed here.

Abstract

Myocardial infarction (MI) remains a dreadful disease around the world, causing irreversible sequelae that shorten life expectancy and reduce quality of life despite current treatment. Here, the authors engineered a cell-enriched myocardial graft, composed of a decellularized myocardial matrix refilled with adipose tissue-derived progenitor cells (EMG-ATDPC). Once applied over the infarcted area in the swine MI model, the EMG-ATDPC improved cardiac function, reduced infarct size, attenuated fibrosis progression, and promoted neovascularization of the ischemic myocardium. The beneficial effects exerted by the EMG-ATDPC and the absence of identified adverse side effects should facilitate its clinical translation as a novel MI therapy in humans.

Citing Articles

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