Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy

Overview

Journal JACC Basic Transl Sci

Date 2018 Sep 1

PMID 30167508

Citations 4

Authors

Bettina Heidecker

Michelle M Kittleson

Edward K Kasper

Ilan S Wittstein

Hunter C Champion

Stuart D Russell

Kenneth L Baughman

Joshua M Hare

Affiliations

Soon will be listed here.

Abstract

Over the last decades, beta-blockers have been a key component of heart failure therapy. However, currently there is no method to identify patients who will benefit from beta-blocking therapy versus those who will be unresponsive or worsen. Furthermore, there is an unmet need to better understand molecular mechanisms through which heart failure therapies, such as beta-blockers, improve cardiac function, in order to design novel targeted therapies. Solving these issues is an important step towards personalized medicine. Here, we present a comprehensive transcriptomic analysis of molecular pathways that are affected by beta-blocking agents and a transcriptomic biomarker to predict therapy response.

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