Synthesis and Characterization of Zinc/Chitosan-Folic Acid Complex

Overview

Journal Heliyon

Specialty Social Sciences

Date 2018 Sep 1

PMID 30167495

Citations 17

Authors

Subhani Bandara

Codi-Anne Carnegie

Chevaun Johnson

Feyisayo Akindoju

Ebonee Williams

Julia M Swaby

Aderemi Oki

Laura E Carson

Affiliations

Soon will be listed here.

Abstract

Therapeutic drug delivery systems using polymeric materials is an emerging field of research. However, the use of certain polymers has gained much-needed attention by the researchers due to their low toxic nature. In recent years, chitosan has gained popularity as a potential biodegradable polymer that can be used as a component in drug delivery systems. In this study, we synthesized a chitosan derivative that is composed of both folic acid and zinc and may serve as a viable component of a drug delivery system. The results of Fourier Transform Infrared Spectroscopy (FTIR), solid-state C Nuclear Magnetic Resonance Spectroscopy (NMR) and UV-visible Spectroscopy demonstrated a substantial difference between chitosan and ZnS/Chitosan-Folic acid derivative. The results were also confirmed using Thermogravimetric Analysis (TGA) and Scanning Electron Microscopy/Energy Dispersive X-ray Spectroscopy (SEM-EDS) techniques. The average particle size of the ZnS/Chitosan-Folic acid system was measured to be 463.67 ± 5.76 nm, showing that the product is within the nano-size range.

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