Differential Expression of Endogenous Mouse Mammary Tumor Virus Genes During Development of the BALB/c Mammary Gland

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1986 Aug 1

PMID 3016314

Citations 3

Authors

J E Knepper

D Medina

J S Butel

Affiliations

Soon will be listed here.

Abstract

Expression of endogenous mouse mammary tumor virus sequences varied over the course of development of the mammary gland during primary pregnancy and lactation in virus-free BALB/c mice. Although RNA from all regions of the genome was detected, both the level and temporal regulation of expression were different for long terminal repeat-, env-, and gag-pol-specific RNAs. Analysis of the methylation status of proviral DNA indicated differential accessibility of the three endogenous units during development. The results demonstrated noncoordinate regulation of mouse mammary tumor virus expression with respect to provirus template utilized and specific transcripts accumulated.

Citing Articles

CDP is a repressor of mouse mammary tumor virus expression in the mammary gland.

Zhu Q, Gregg K, Lozano M, Liu J, Dudley J J Virol. 2000; 74(14):6348-57.

PMID: 10864645 PMC: 112141. DOI: 10.1128/jvi.74.14.6348-6357.2000.

The mouse mammary tumor virus env gene is the source of a CD8+ T-cell-stimulating peptide presented by a major histocompatibility complex class I molecule in a murine thymoma.

Malarkannan S, Serwold T, Nguyen V, Sherman L, Shastri N Proc Natl Acad Sci U S A. 1996; 93(24):13991-6.

PMID: 8943048 PMC: 19482. DOI: 10.1073/pnas.93.24.13991.

Detection and characterization of a glycoprotein encoded by the mouse mammary tumor virus long terminal repeat gene.

Butel J J Virol. 1991; 65(11):6051-60.

PMID: 1656086 PMC: 250273. DOI: 10.1128/JVI.65.11.6051-6060.1991.

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