Enantioselective Intramolecular Copper-Catalyzed Borylacylation

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2018 Aug 31

PMID 30160825

Citations 18

Authors

Andrew Whyte

Katherine I Burton

Jingli Zhang

Mark Lautens

Affiliations

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Abstract

An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon-boron bond provides a platform for a wide array of diversification.

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