The Netrin-4/Laminin γ1/Neogenin-1 Complex Mediates Migration in SK-N-SH Neuroblastoma Cells

Overview

Journal Cell Adh Migr

Specialty Cell Biology

Date 2018 Aug 31

PMID 30160193

Citations 7

Authors

Andrea A Villanueva

Sofia Puvogel

Pablo Lois

Ernesto Munoz-Palma

Manuel Ramirez Orellana

Fabiana Lubieniecki

Fernando Casco Claro

Ivan Gallegos

Javier Garcia-Castro

Pilar Sanchez-Gomez

Vicente A Torres

Veronica Palma

Affiliations

Soon will be listed here.

Abstract

Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), a laminin-related protein, has been proposed as a key factor to target NB metastasis, although there is controversy about its function. Here, we show that NTN4 is broadly expressed in tumor, stroma and blood vessels of NB patient samples. Furthermore, NTN4 was shown to act as a cell adhesion molecule required for the migration induced by Neogenin-1 (NEO1) in SK-N-SH neuroblastoma cells. Therefore, we propose that NTN4, by forming a ternary complex with Laminin γ1 (LMγ1) and NEO1, acts as an essential extracellular matrix component, which induces the migration of SK-N-SH cells.

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