Systemic Immunomodulatory Treatments for Atopic Dermatitis: Protocol for a Systematic Review with Network Meta-analysis

Overview

Journal BMJ Open

Specialty General Medicine

Date 2018 Aug 31

PMID 30158235

Citations 6

Authors

Aaron Mark Drucker

Alexandra Ellis

Zarif Jabbar-Lopez

Zenas Z N Yiu

Bernd W M Arents

Tim Burton

Phyllis I Spuls

Denise Kuster

Jochen Schmitt

Carsten Flohr

Affiliations

Soon will be listed here.

Abstract

Introduction: There are numerous new systemic treatments for atopic dermatitis in various stages of development and most are being compared with placebo rather than active comparators. In order to understand the relative efficacy and safety of existing and new treatments for atopic dermatitis, robust mixed comparisons (ie, direct and indirect) would be beneficial. To address this gap, this protocol describes methods for a systematic review and network meta-analysis of systemic treatments for atopic dermatitis.

Methods And Analysis: We will update the search of a previous systematic review, including searches of the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Latin American and Caribbean Health Science Information database and the Global Resource of EczemA Trials database in addition to clinical trial protocol registries. Title, abstract and full paper screening as well as data extraction will be conducted in duplicate by independent researchers. Primary outcomes include efficacy with regards to clinician-reported signs and patient-reported symptoms and safety with regards to withdrawal from treatment due to adverse events and the occurrence of serious adverse events. Secondary outcomes will include change in quality of life and itch severity. Where possible and appropriate, network meta-analysis will be performed for each outcome using a random-effects model within a Bayesian framework. If appropriate, the review will be transitioned to a living review with continuous updating of the analysis.

Ethics And Dissemination: Dissemination in a peer-reviewed scientific journal is planned.

Prospero Registration Number: CRD42018088112; Pre-results.

Citing Articles

Data-driven research on eczema: Systematic characterization of the field and recommendations for the future.

Duverdier A, Custovic A, Tanaka R Clin Transl Allergy. 2022; 12(6):e12170.

PMID: 35686200 PMC: 9172212. DOI: 10.1002/clt2.12170.

Comparative Efficacy of Targeted Systemic Therapies for Moderate to Severe Atopic Dermatitis without Topical Corticosteroids: Systematic Review and Network Meta-analysis.

Silverberg J, Hong H, Thyssen J, Calimlim B, Joshi A, Teixeira H Dermatol Ther (Heidelb). 2022; 12(5):1181-1196.

PMID: 35435637 PMC: 9110624. DOI: 10.1007/s13555-022-00721-1.

Systemic Immunomodulatory Treatments for Atopic Dermatitis: Update of a Living Systematic Review and Network Meta-analysis.

Drucker A, Morra D, Prieto-Merino D, Ellis A, Yiu Z, Rochwerg B JAMA Dermatol. 2022; 158(5):523-532.

PMID: 35293977 PMC: 8928094. DOI: 10.1001/jamadermatol.2022.0455.

International observational atopic dermatitis cohort to follow natural history and treatment course: TARGET-DERM AD study design and rationale.

Abuabara K, Silverberg J, Simpson E, Paller A, Eichenfield L, Bissonnette R BMJ Open. 2020; 10(11):e039928.

PMID: 33247014 PMC: 7703415. DOI: 10.1136/bmjopen-2020-039928.

Systemic Immunomodulatory Treatments for Patients With Atopic Dermatitis: A Systematic Review and Network Meta-analysis.

Drucker A, Ellis A, Bohdanowicz M, Mashayekhi S, Yiu Z, Rochwerg B JAMA Dermatol. 2020; 156(6):659-667.

PMID: 32320001 PMC: 7177646. DOI: 10.1001/jamadermatol.2020.0796.

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