Designing Stem Cell Niches for Differentiation and Self-renewal

Overview

Journal J R Soc Interface

Specialties Biology
Biomedical Engineering
Biophysics

Date 2018 Aug 31

PMID 30158185

Citations 54

Authors

Hannah Donnelly

Manuel Salmeron-Sanchez

Matthew J Dalby

Affiliations

Soon will be listed here.

Abstract

Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in contact with their specialized microenvironment, termed the Niches provide structural and functional cues that are both biochemical and biophysical, stem cells integrate this complex array of signals with intrinsic regulatory networks to meet physiological demands. Although, some of these regulatory mechanisms remain poorly understood or difficult to harness with traditional culture systems. Biomaterial strategies are being developed that aim to recapitulate stem cell niches, by engineering microenvironments with physiological-like niche properties that aim to elucidate stem cell-regulatory mechanisms, and to harness their regenerative capacity In the future, engineered niches will prove important tools for both regenerative medicine and therapeutic discoveries.

Citing Articles

An engineered biomaterial to harness the differentiation potential of endogenous human gingival mesenchymal stem cells (hGMSCs).

Hasani-Sadrabadi M, Yuan W, Sevari S, Yu B, Ansari S, Moshaverinia A Front Dent Med. 2025; 4:1235096.

PMID: 39916923 PMC: 11797836. DOI: 10.3389/fdmed.2023.1235096.

Supragel-mediated efficient generation of pancreatic progenitor clusters and functional glucose-responsive islet-like clusters.

Ma H, Xu L, Wu S, Wang S, Li J, Ai S Bioact Mater. 2024; 41:1-14.

PMID: 39101030 PMC: 11292262. DOI: 10.1016/j.bioactmat.2024.07.007.

Stem Cell-Based Acellular Therapy: Insight into Biogenesis, Bioengineering and Therapeutic Applications of Exosomes.

Choudhery M, Arif T, Mahmood R, Harris D Biomolecules. 2024; 14(7).

PMID: 39062506 PMC: 11275160. DOI: 10.3390/biom14070792.

Role of Hedgehog Signaling Pathways in Multipotent Mesenchymal Stem Cells Differentiation.

Wu M, Mi J, Qu G, Zhang S, Jian Y, Gao C Cell Transplant. 2024; 33:9636897241244943.

PMID: 38695366 PMC: 11067683. DOI: 10.1177/09636897241244943.

Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications.

Ambattu L, Yeo L Biophys Rev (Melville). 2024; 4(2):021301.

PMID: 38504927 PMC: 10903386. DOI: 10.1063/5.0127122.

References

Discher D, Janmey P, Wang Y . Tissue cells feel and respond to the stiffness of their substrate. Science. 2005; 310(5751):1139-43. DOI: 10.1126/science.1116995. View

Curtis A, Varde M . CONTROL OF CELL BEHAVIOR: TOPOLOGICAL FACTORS. J Natl Cancer Inst. 1964; 33:15-26. View

Daley W, Gulfo K, Sequeira S, Larsen M . Identification of a mechanochemical checkpoint and negative feedback loop regulating branching morphogenesis. Dev Biol. 2009; 336(2):169-82. PMC: 3183484. DOI: 10.1016/j.ydbio.2009.09.037. View

Wang N, Butler J, Ingber D . Mechanotransduction across the cell surface and through the cytoskeleton. Science. 1993; 260(5111):1124-7. DOI: 10.1126/science.7684161. View

Huebsch N, Arany P, Mao A, Shvartsman D, Ali O, Bencherif S . Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater. 2010; 9(6):518-26. PMC: 2919753. DOI: 10.1038/nmat2732. View

Pammolli F, Magazzini L, Riccaboni M . The productivity crisis in pharmaceutical R&D. Nat Rev Drug Discov. 2011; 10(6):428-38. DOI: 10.1038/nrd3405. View

Salomoni P, Calegari F . Cell cycle control of mammalian neural stem cells: putting a speed limit on G1. Trends Cell Biol. 2010; 20(5):233-43. DOI: 10.1016/j.tcb.2010.01.006. View

Cotovio J, Grandidier M, Portes P, Roguet R, Rubinstenn G . The in vitro skin irritation of chemicals: optimisation of the EPISKIN prediction model within the framework of the ECVAM validation process. Altern Lab Anim. 2005; 33(4):329-49. DOI: 10.1177/026119290503300403. View

Sunyer R, Conte V, Escribano J, Elosegui-Artola A, Labernadie A, Valon L . Collective cell durotaxis emerges from long-range intercellular force transmission. Science. 2016; 353(6304):1157-61. DOI: 10.1126/science.aaf7119. View

10.

Vicente R, Noel D, Pers Y, Apparailly F, Jorgensen C . Deregulation and therapeutic potential of microRNAs in arthritic diseases. Nat Rev Rheumatol. 2015; 12(4):211-20. DOI: 10.1038/nrrheum.2015.162. View

11.

Curran J, Chen R, Hunt J . The guidance of human mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate. Biomaterials. 2006; 27(27):4783-93. DOI: 10.1016/j.biomaterials.2006.05.001. View

12.

Cortes F, Debacker C, Peault B, Labastie M . Differential expression of KDR/VEGFR-2 and CD34 during mesoderm development of the early human embryo. Mech Dev. 1999; 83(1-2):161-4. DOI: 10.1016/s0925-4773(99)00030-1. View

13.

Boyer L, Lee T, Cole M, Johnstone S, Levine S, Zucker J . Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005; 122(6):947-56. PMC: 3006442. DOI: 10.1016/j.cell.2005.08.020. View

14.

Celiz A, Smith J, Patel A, Hook A, Rajamohan D, George V . Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation. Adv Mater. 2015; 27(27):4006-12. PMC: 4862031. DOI: 10.1002/adma.201501351. View

15.

Aota S, Nomizu M, Yamada K . The short amino acid sequence Pro-His-Ser-Arg-Asn in human fibronectin enhances cell-adhesive function. J Biol Chem. 1994; 269(40):24756-61. View

16.

Dalby M, Gadegaard N, Herzyk P, Sutherland D, Agheli H, Wilkinson C . Nanomechanotransduction and interphase nuclear organization influence on genomic control. J Cell Biochem. 2007; 102(5):1234-44. DOI: 10.1002/jcb.21354. View

17.

Cosgrove B, Mui K, Driscoll T, Caliari S, Mehta K, Assoian R . N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells. Nat Mater. 2016; 15(12):1297-1306. PMC: 5121068. DOI: 10.1038/nmat4725. View

18.

Zhang Y, Aleman J, Shin S, Kilic T, Kim D, Mousavi Shaegh S . Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors. Proc Natl Acad Sci U S A. 2017; 114(12):E2293-E2302. PMC: 5373350. DOI: 10.1073/pnas.1612906114. View

19.

Kinney M, McDevitt T . Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Trends Biotechnol. 2012; 31(2):78-84. PMC: 3557560. DOI: 10.1016/j.tibtech.2012.11.001. View

20.

McNamara L, Burchmore R, Riehle M, Herzyk P, Biggs M, Wilkinson C . The role of microtopography in cellular mechanotransduction. Biomaterials. 2012; 33(10):2835-47. DOI: 10.1016/j.biomaterials.2011.11.047. View