Xerosis Cutis and Associated Co-factors in Women with Prurigo Nodularis

Overview

Journal An Bras Dermatol

Specialty Dermatology

Date 2018 Aug 30

PMID 30156616

Citations 6

Authors

Sevgi Akarsu

Ozlem Ozbagcivan

Turna Ilknur

Fatma Semiz

Burcu Bahar Inci

Emel Fetil

Affiliations

Soon will be listed here.

Abstract

Background: Current data regarding the associated factors of prurigo nodularis are still uncertain, except for atopic predisposition.

Objectives: The purposes of this study were to (1) determine the frequencies of xerosis and other accompanying diseases of female patients with prurigo nodularis; (2) compare the demographic, clinical and accompanying disease characteristics by grouping these patients according to whether they have associated xerosis (who were subsequently subgrouped as atopic or non-atopic) or not.

Methods: In this retrospective descriptive study, 80 females with PN were categorized according to the accompanying diseases (dermatological, systemic, neurological, psychogenic, mixed, or undetermined origin).

Results: A total of 45 associated co-factors including dermatological in 63 (78.8%), systemic in 57 (71.3%), psychological in 33 (41.3%) and neurological co-factors in 14 (17.5%) of all patients with prurigo nodularis were detected. Xerosis was observed in 48 (60%) patients (non-atopic co-factors in 66.7% of them). The ratio of patients with mixed co-factors, dermatological+systemic co-factors and dermatological+systemic+psychological co-factors were found to be significantly higher in patients with xerosis compared to those without xerosis.

Study Limitations: Our study has certain limitations such as the absence of an age-matched control group, absence of follow-up data and the fact that the diagnosis of xerosis has not been based on objective methods.

Conclusions: Xerosis has been identified in more than half of the patients with PN and it has been determined that in most patients xerosis is associated especially with diabetes mellitus and other conditions related to prurigo nodularis.

Citing Articles

The Significant Role of Atopic Skin Diathesis in Prurigo Nodularis.

Erdem Y, Ntousounous O, Ozkaya E Sisli Etfal Hastan Tıp Bul. 2025; 58(4):477-482.

PMID: 39816422 PMC: 11729828. DOI: 10.14744/SEMB.2024.46144.

Prurigo Nodularis: Pathogenesis and the Horizon of Potential Therapeutics.

Yook H, Lee J Int J Mol Sci. 2024; 25(10).

PMID: 38791201 PMC: 11121340. DOI: 10.3390/ijms25105164.

Pruritus in Pregnancy.

Stefaniak A, Pereira M, Zeidler C, Stander S Am J Clin Dermatol. 2022; 23(2):231-246.

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Cognitive Impairment in Inpatients with Prurigo Nodularis and Psychiatric Comorbidities.

Lanza G, Cosentino F, Ferri R, Lanuzza B, Siragusa M, Tripodi M Int J Environ Res Public Health. 2021; 18(12).

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Criteria Suggestive of Psychological Components of Itch and Soma-toform Itch: Study of a Large Sample of Patients with Chronic Pruritus.

Schneider G, Grebe A, Bruland P, Heuft G, Stander S Acta Derm Venereol. 2020; 100(6):adv00075.

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