Ligand-assisted Palladium-catalyzed C-H Alkenylation of Aliphatic Amines for the Synthesis of Functionalized Pyrrolidines

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Aug 30

PMID 30155203

Citations 11

Authors

Chuan He

Matthew J Gaunt

Affiliations

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Abstract

The development of a ligand-assisted Pd-catalyzed C-H alkenylation of aliphatic amines is reported. Our studies indicated that an amino-acid-derived ligand renders the C-H bond activation step reversible and promotes the traditionally difficult alkenylation process. The C(sp)-H alkenylation proceeds through a 5-membered-ring cyclopalladation pathway that allows access to complex aliphatic heterocycles that could be useful to practioners of synthetic and medicinal chemistry.

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