Proteases and Their Inhibitors in Chronic Obstructive Pulmonary Disease

Overview

Journal J Clin Med

Specialty General Medicine

Date 2018 Aug 30

PMID 30154365

Citations 25

Authors

Tapan Dey

Jatin Kalita

Sinead Weldon

Clifford C Taggart

Affiliations

Soon will be listed here.

Abstract

In the context of respiratory disease, chronic obstructive pulmonary disease (COPD) is the leading cause of mortality worldwide. Despite much development in the area of drug development, currently there are no effective medicines available for the treatment of this disease. An imbalance in the protease: Antiprotease ratio in the COPD lung remains an important aspect of COPD pathophysiology and several studies have shown the efficacy of antiprotease therapy in both in vitro and in vivo COPD models. However more in-depth studies will be required to validate the efficacy of lead drug molecules targeting these proteases. This review discusses the current status of protease-directed drugs used for treating COPD and explores the future prospects of utilizing the potential of antiprotease-based therapeutics as a treatment for this disease.

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