Synthesis and Biological Evaluation of Novel Asymmetric Naphthalene Diimide Derivatives As Anticancer Agents Depending on ROS Generation

Overview

Journal Medchemcomm

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Aug 29

PMID 30151093

Citations 2

Authors

Xiaojuan Xu

Senzhen Wang

Yuan Chang

Chaochao Ge

Xinna Li

Yongli Feng

Songqiang Xie

Chaojie Wang

Fujun Dai

Wen Luo

Affiliations

Soon will be listed here.

Abstract

Naphthalenetetracarboxylic diimide (NDI) is widely used as a photoelectric material in the field of medicine. A series of asymmetric naphthalene diimide derivatives were synthesized and evaluated for their anticancer properties by various experimental assays. As the representative compound, exerted significantly greater inhibitory effects on hepatoma cells SMMC-7721 and Hep G2 with an IC value of 1.48 ± 0.43 μM and 1.70 ± 0.53 μM, respectively, than normal hepatocytes QSG-7701 with an IC value of 7.11 ± 0.08 μM. Treatment with compound (3 μM) for 48 h resulted in apoptosis of SMMC-7721 cells and Hep G2 cells with 52.1% and 67.8% apoptotic cells, respectively. Compound induced autophagy and suppressed the migration of hepatoma cells in a concentration-dependent manner, resulting from the generation of reactive oxygen species (ROS). Based on its biological ability, compound was considered as a potent anticancer agent.

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