Single Nucleotide Polymorphisms in Vitamin D Receptor Gene Affect Birth Weight and the Risk of Preterm Birth: Results From the "Mamma & Bambino" Cohort and A Meta-Analysis

Overview

Journal Nutrients

Date 2018 Aug 29

PMID 30150529

Citations 39

Authors

Martina Barchitta

Andrea Maugeri

Maria Clara La Rosa

Roberta Magnano San Lio

Giuliana Favara

Marco Panella

Antonio Cianci

Antonella Agodi

Affiliations

Soon will be listed here.

Abstract

The effect of vitamin D receptor gene (VDR) polymorphisms on adverse pregnancy outcomes-including preterm birth (PTB), low birth weight and small for gestational age-is currently under debate. We investigated 187 mother-child pairs from the Italian "Mamma & Bambino" cohort to evaluate the association of maternal VDR polymorphisms-BsmI, ApaI, FokI and TaqI-with neonatal anthropometric measures and the risk of PTB. To corroborate our results, we conducted a meta-analysis of observational studies. For the FokI polymorphism, we showed that gestational duration and birth weight decreased with increasing number of A allele ( = 0.040 and = 0.010, respectively). Compared to the GG and GA genotypes, mothers who carried the AA genotype exhibited higher PTB risk (OR = 12.049; 95% CI = 2.606⁻55.709; = 0.001) after adjusting for covariates. The meta-analysis confirmed this association under the recessive model (OR = 3.67, 95%CI 1.18⁻11.43), and also pointed out the protective effect of BsmI polymorphism against the risk of PTB under the allelic (A vs. G: OR = 0.74; 95%CI 0.59⁻0.93) and recessive (AA vs. GG + AG: OR = 0.62; 95%CI 0.43⁻0.89) models. Our results suggest the association between some maternal VDR polymorphisms with neonatal anthropometric measures and the risk of PTB.

Citing Articles

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