Papillomavirus DNA in Warts of Immunosuppressed Renal Allograft Recipients

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1986 Jan 1

PMID 3015050

Citations 13

Authors

A Gassenmaier

P Fuchs

H Schell

H Pfister

Affiliations

Soon will be listed here.

Abstract

Renal allograft recipients were shown to have an increased incidence of warts and skin cancers. We examined 148 patients for evidence of wart virus infections and tested for papillomavirus types, which are known to be associated with human malignancies. Of the 148, 36 (24.3%) patients were afflicted with warts at the end of our study period, in contrast to 5 of 148 (3.3%) before transplantation. DNA from 16 different biopsies was extracted by phenol treatment for further virological studies. DNA of human papillomavirus (HPV) 2 was detected three times, DNA of HPV 4 and 10 twice, and DNA of HPV 3 and 16 once each by blot hybridization. One probe led to strong signals with HPV types previously found only in epidermodysplasia verruciformis patients. A correlation between histology and virus type existed in cases of HPV 2, 3, 4, and 10 infections.

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