» Articles » PMID: 30148086

A Study on Psychiatric Disorders, Body Image Disturbances, and Self-Esteem in Patients of Cushing's Disease

Overview
Specialty Endocrinology
Date 2018 Aug 28
PMID 30148086
Citations 2
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Cushing's disease (CD) is a rare endocrine disorder associated with increased serum levels of cortisol secreted due to an underlying tumour in pituitary. Psychiatric disturbances like depression, psychosis, mania along with body image disturbances are seen in patients of CD. Hence, we undertook this research to find the prevalence and type of psychiatric disorders, body image disturbances, and self-esteem in patients of CD.

Materials And Methods: Thirty-five patients diagnosed as CD as per the standard criteria by the endocrinologist were recruited after informed consent and ethics approval. Proforma with demographic details, Structured Clinical Interview for DSM-IV, Beck Depression Inventory (BDI), Rosenberg Self-Esteem Scale, and Body Image Concern Inventory were used for assessment of the aims.

Results: 65% patients had psychopathology with 21% patients having major depressive disorder, 62% patients had mild, and 28% had moderate depression on BDI. 50% patients had body image disturbances and 60% had low self-esteem. Depression was found to have a negative correlation with self-esteem and positive correlation with body image disturbances.

Conclusion: A high prevalence of psychopathology is seen in patients of CD which may often go undetected. Liaison with the endocrinologist would also work towards improving the issues of body image disturbances and self-esteem for better prognosis for the patient.

Citing Articles

Electroconvulsive Therapy in Psychiatric Disorders: A Narrative Review Exploring Neuroendocrine-Immune Therapeutic Mechanisms and Clinical Implications.

Rojas M, Ariza D, Ortega A, Riano-Garzon M, Chavez-Castillo M, Perez J Int J Mol Sci. 2022; 23(13).

PMID: 35805923 PMC: 9266340. DOI: 10.3390/ijms23136918.


Mania as Debut of Cushing's Syndrome.

Martinez R, Rodriguez R, Ariza M, Spuch C, Olivares J Case Rep Psychiatry. 2020; 2020:9127632.

PMID: 32190397 PMC: 7073507. DOI: 10.1155/2020/9127632.

References
1.
Conaglen H, de Jong D, Crawford V, Elston M, Conaglen J . Body Image Disturbance in Acromegaly Patients Compared to Nonfunctioning Pituitary Adenoma Patients and Controls. Int J Endocrinol. 2015; 2015:624872. PMC: 4452843. DOI: 10.1155/2015/624872. View

2.
de Kloet E, Vreugdenhil E, Oitzl M, Joels M . Brain corticosteroid receptor balance in health and disease. Endocr Rev. 1998; 19(3):269-301. DOI: 10.1210/edrv.19.3.0331. View

3.
Siegel J, Yancey A, Aneshensel C, Schuler R . Body image, perceived pubertal timing, and adolescent mental health. J Adolesc Health. 1999; 25(2):155-65. DOI: 10.1016/s1054-139x(98)00160-8. View

4.
Machado M, Alcantara A, Pereira A, Cescato V, Castro Musolino N, de Mendonca B . Negative correlation between tumour size and cortisol/ACTH ratios in patients with Cushing's disease harbouring microadenomas or macroadenomas. J Endocrinol Invest. 2016; 39(12):1401-1409. DOI: 10.1007/s40618-016-0504-y. View

5.
Ross E, Linch D . Cushing's syndrome--killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet. 1982; 2(8299):646-9. DOI: 10.1016/s0140-6736(82)92749-0. View