» Articles » PMID: 30137226

ImaGEO: Integrative Gene Expression Meta-analysis from GEO Database

Overview
Journal Bioinformatics
Specialty Biology
Date 2018 Aug 24
PMID 30137226
Citations 80
Authors
Affiliations
Soon will be listed here.
Abstract

Summary: The Gene Expression Omnibus (GEO) database provides an invaluable resource of publicly available gene expression data that can be integrated and analyzed to derive new hypothesis and knowledge. In this context, gene expression meta-analysis (geMAs) is increasingly used in several fields to improve study reproducibility and discovering robust biomarkers. Nevertheless, integrating data is not straightforward without bioinformatics expertise. Here, we present ImaGEO, a web tool for geMAs that implements a complete and comprehensive meta-analysis workflow starting from GEO dataset identifiers. The application integrates GEO datasets, applies different meta-analysis techniques and provides functional analysis results in an easy-to-use environment. ImaGEO is a powerful and useful resource that allows researchers to integrate and perform meta-analysis of GEO datasets to lead robust findings for biomarker discovery studies.

Availability And Implementation: ImaGEO is accessible at http://bioinfo.genyo.es/imageo/.

Supplementary Information: Supplementary data are available at Bioinformatics online.

Citing Articles

Gene Expression Signatures of Smoking and Acute Myocardial Infarction: A Blood Transcriptome Analysis.

Liu F, Yan Y, Zhang H, Li K Mediators Inflamm. 2025; 2025():2431090.

PMID: 39845197 PMC: 11753852. DOI: 10.1155/mi/2431090.


The landscape of immunogenic cell death-related genes predicts the overall survival and immune infiltration status of non-small-cell lung carcinoma.

Zhang J, Li H, Zhang X, Yang Y, Sun Y Heliyon. 2025; 11(1):e40869.

PMID: 39834423 PMC: 11745784. DOI: 10.1016/j.heliyon.2024.e40869.


Analysis of regulatory patterns of NLRP3 corpuscles and related genes and the role of macrophage polarization in atherosclerosis based on online database.

Shen W, Wu T, Liu Q, Ke B Mol Genet Genomics. 2024; 300(1):7.

PMID: 39725776 DOI: 10.1007/s00438-024-02216-4.


Integrative analysis of the efficacy and pharmacological mechanism of Xuefu Zhuyu decoction in idiopathic pulmonary fibrosis via evidence-based medicine, bioinformatics, and experimental verification.

Zhang H, Hua H, Liu J, Wang C, Zhu C, Xia Q Heliyon. 2024; 10(19):e38122.

PMID: 39416822 PMC: 11481653. DOI: 10.1016/j.heliyon.2024.e38122.


Bioinformatics-Based Identification of Key Prognostic Genes in Neuroblastoma with a Focus on Immune Cell Infiltration and Diagnostic Potential of VGF.

Guo Q, Xiao Y, Chu J, Sun Y, Li S, Zhang S Pharmgenomics Pers Med. 2024; 17:453-472.

PMID: 39403102 PMC: 11472764. DOI: 10.2147/PGPM.S461072.