Symptoms and Health-related Quality of Life in Japanese Patients with Primary Biliary Cholangitis

Overview

Journal Sci Rep

Specialty Science

Date 2018 Aug 24

PMID 30135523

Citations 9

Authors

Minami Yagi

Atsushi Tanaka

Masanori Abe

Tadashi Namisaki

Hitoshi Yoshiji

Atsushi Takahashi

Hiromasa Ohira

Atsumasa Komori

Satoshi Yamagiwa

Kentaro Kikuchi

Tetsuya Yasunaka

Akinobu Takaki

Yoshiyuki Ueno

Akira Honda

Yasushi Matsuzaki

Hajime Takikawa

Affiliations

Soon will be listed here.

Abstract

Although patients with primary biliary cholangitis (PBC) experience a variety of symptoms that could impair health-related quality of life (HRQOL), no studies regarding symptoms and impact of PBC on HRQOL have been performed in Asian countries. Herein, we aimed to evaluate symptoms and HRQOL in Japanese PBC patients. We performed a multicenter, observational, cross-sectional study. The PBC-40 and the short form (SF)-36 were used as measures of symptoms and HRQOL. Four-hundred-ninety-six patients with PBC were enrolled. In the PBC-40, the average score was highest in the emotional domain, followed by the fatigue domain. The HRQOL measured using SF-36 was also impaired, especially in the physical and role-social components. After adjustments of variables, female sex, younger age at diagnosis, and lower serum albumin level were independently associated with fatigue scores, while a longer follow-up period and lower serum albumin levels were associated with itch scores.

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References

Mells G, Pells G, Newton J, Bathgate A, Burroughs A, Heneghan M . Impact of primary biliary cirrhosis on perceived quality of life: the UK-PBC national study. Hepatology. 2013; 58(1):273-83. DOI: 10.1002/hep.26365. View

Nakano T, Inoue K, Hirohara J, Arita S, Higuchi K, Omata M . Long-term prognosis of primary biliary cirrhosis (PBC) in Japan and analysis of the factors of stage progression in asymptomatic PBC (a-PBC). Hepatol Res. 2002; 22(4):250-260. DOI: 10.1016/s1386-6346(01)00148-6. View

Azemoto N, Abe M, Murata Y, Hiasa Y, Hamada M, Matsuura B . Early biochemical response to ursodeoxycholic acid predicts symptom development in patients with asymptomatic primary biliary cirrhosis. J Gastroenterol. 2009; 44(6):630-4. DOI: 10.1007/s00535-009-0051-9. View

Sun Y, Zhang W, Evans J, Floreani A, Zou Z, Nishio Y . Autotaxin, Pruritus and Primary Biliary Cholangitis (PBC). Autoimmun Rev. 2016; 15(8):795-800. DOI: 10.1016/j.autrev.2016.03.019. View

Nevens F, Andreone P, Mazzella G, Strasser S, Bowlus C, Invernizzi P . A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis. N Engl J Med. 2016; 375(7):631-43. DOI: 10.1056/NEJMoa1509840. View

Newton J, Gibson G, Tomlinson M, Wilton K, Jones D . Fatigue in primary biliary cirrhosis is associated with excessive daytime somnolence. Hepatology. 2006; 44(1):91-8. DOI: 10.1002/hep.21230. View

Newton J, Bhala N, Burt J, Jones D . Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure. J Hepatol. 2006; 44(4):776-83. DOI: 10.1016/j.jhep.2005.12.012. View

Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa K . Translation, adaptation, and validation of the SF-36 Health Survey for use in Japan. J Clin Epidemiol. 1998; 51(11):1037-44. DOI: 10.1016/s0895-4356(98)00095-x. View

Kaplan M, Gershwin M . Primary biliary cirrhosis. N Engl J Med. 2005; 353(12):1261-73. DOI: 10.1056/NEJMra043898. View

10.

Lindor K, Gershwin M, Poupon R, Kaplan M, Bergasa N, Heathcote E . Primary biliary cirrhosis. Hepatology. 2009; 50(1):291-308. DOI: 10.1002/hep.22906. View

11.

Newton J, Hudson M, Tachtatzis P, Sutcliffe K, Pairman J, Burt J . Population prevalence and symptom associations of autonomic dysfunction in primary biliary cirrhosis. Hepatology. 2007; 45(6):1496-505. DOI: 10.1002/hep.21609. View

12.

Jacoby A, Rannard A, Buck D, Bhala N, Newton J, James O . Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis. Gut. 2005; 54(11):1622-9. PMC: 1774759. DOI: 10.1136/gut.2005.065862. View

13.

Quarneti C, Muratori P, Lalanne C, Fabbri A, Menichella R, Granito A . Fatigue and pruritus at onset identify a more aggressive subset of primary biliary cirrhosis. Liver Int. 2014; 35(2):636-41. DOI: 10.1111/liv.12560. View

14.

Beuers U, Kremer A, Bolier R, Oude Elferink R . Pruritus in cholestasis: facts and fiction. Hepatology. 2014; 60(1):399-407. DOI: 10.1002/hep.26909. View

15.

. Guidelines for the management of primary biliary cirrhosis: The Intractable Hepatobiliary Disease Study Group supported by the Ministry of Health, Labour and Welfare of Japan. Hepatol Res. 2014; 44 Suppl S1:71-90. DOI: 10.1111/hepr.12270. View

16.

Floreani A, Tanaka A, Bowlus C, Gershwin M . Geoepidemiology and changing mortality in primary biliary cholangitis. J Gastroenterol. 2017; 52(6):655-662. DOI: 10.1007/s00535-017-1333-2. View

17.

Carbone M, Mells G, Pells G, Dawwas M, Newton J, Heneghan M . Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid. Gastroenterology. 2012; 144(3):560-569.e7. DOI: 10.1053/j.gastro.2012.12.005. View

18.

Tanaka A, Hirohara J, Nakanuma Y, Tsubouchi H, Takikawa H . Biochemical responses to bezafibrate improve long-term outcome in asymptomatic patients with primary biliary cirrhosis refractory to UDCA. J Gastroenterol. 2014; 50(6):675-82. DOI: 10.1007/s00535-014-0998-z. View

19.

Selmi C, Gershwin M, Lindor K, Worman H, Gold E, Watnik M . Quality of life and everyday activities in patients with primary biliary cirrhosis. Hepatology. 2007; 46(6):1836-43. PMC: 3148769. DOI: 10.1002/hep.21953. View

20.

Newton J, Davidson A, Kerr S, Bhala N, Pairman J, Burt J . Autonomic dysfunction in primary biliary cirrhosis correlates with fatigue severity. Eur J Gastroenterol Hepatol. 2007; 19(2):125-32. DOI: 10.1097/01.meg.0000252629.96043.67. View