Update on the Indications and Results of Sentinel Node Mapping in Upper GI Cancer

Overview

Journal Clin Exp Metastasis

Specialty Oncology

Date 2018 Aug 23

PMID 30132238

Citations 7

Authors

Masashi Takeuchi

Hiroya Takeuchi

Hirofumi Kawakubo

Yuko Kitagawa

Affiliations

Soon will be listed here.

Abstract

The clinical utilization of sentinel node (SN) mapping for early esophageal cancer or gastric cancer has been unclear for a long time. However, previous investigations regarding SN mapping of these cancers have shown relatively good results with regard to the detection rate and diagnostic accuracy for determining the lymph node status. SN mapping helps obtain information about individual metastatic status and allows the modification of the operation in early-stage upper gastrointestinal (GI) disease. Radio-guided methods for identifying SNs in early esophageal cancer have been established via endoscopic injection of technetium-99m tin colloid. Previous studies have reported that the SN concept seems valid, and radio-guided SN mapping can be feasible in cT1N0 esophageal cancer. SN navigation surgery are believed to have potential as strategies for minimally invasive modified surgery for early esophageal cancer. A Japanese study group conducted a prospective multicenter trial of SN mapping for early gastric cancer using a dual tracer method with radioactive colloid and blue dyes; they demonstrated a high detection rate and accuracy for determining the metastatic status based on SN mapping. Subsequently, minimized gastrectomy, including partial gastrectomy and segmental gastrectomy with individualized selective and modified lymphadenectomy for early gastric cancer with a negative SN has been performed to evaluate the long-term survival and postoperative quality of life (QOL) in a multicenter prospective trial. This study verified the SN concept in early-stage upper GI disease with cN0 and found that function-preserving esophagectomy or gastrectomy may help maintain patients' post-surgical QOL.

Citing Articles

Real-World Data of Esophageal Malignancies Managed Under the Government Scheme From a Tertiary Cancer Center in South India.

Teja R, Bhaskar R, Yadlapalli D, Kukunuri S, Mohan R Cureus. 2025; 17(1):e77850.

PMID: 39991427 PMC: 11845311. DOI: 10.7759/cureus.77850.

Cancer metastasis through the lymphatic versus blood vessels.

Leong S, Witte M Clin Exp Metastasis. 2024; 41(4):387-402.

PMID: 38940900 PMC: 11374872. DOI: 10.1007/s10585-024-10288-0.

Comprehensive Rehabilitation Strategies in Esophageal Cancer: A Case Report of Enhancing Recovery and Quality of Life.

Gabada R, Athawale V Cureus. 2024; 16(4):e57893.

PMID: 38725790 PMC: 11079694. DOI: 10.7759/cureus.57893.

Assessment of Lymph Node Metastasis in Patients With Gastric Cancer to Identify Those Suitable for Middle Segmental Gastrectomy.

Khalayleh H, Kim Y, Yoon H, Ryu K JAMA Netw Open. 2021; 4(3):e211840.

PMID: 33729506 PMC: 7970333. DOI: 10.1001/jamanetworkopen.2021.1840.

Precision medicine for gastrointestinal cancer: Recent progress and future perspective.

Matsuoka T, Yashiro M World J Gastrointest Oncol. 2020; 12(1):1-20.

PMID: 31966910 PMC: 6960076. DOI: 10.4251/wjgo.v12.i1.1.

References

Kitagawa Y, Takeuchi H, Takagi Y, Natsugoe S, Terashima M, Murakami N . Sentinel node mapping for gastric cancer: a prospective multicenter trial in Japan. J Clin Oncol. 2013; 31(29):3704-10. DOI: 10.1200/JCO.2013.50.3789. View

Kinugasa S, Tachibana M, Yoshimura H, Ueda S, Fujii T, Dhar D . Postoperative pulmonary complications are associated with worse short- and long-term outcomes after extended esophagectomy. J Surg Oncol. 2004; 88(2):71-7. DOI: 10.1002/jso.20137. View

Ishikawa K, Yasuda K, Shiromizu A, Etoh T, Shiraishi N, Kitano S . Laparoscopic sentinel node navigation achieved by infrared ray electronic endoscopy system in patients with gastric cancer. Surg Endosc. 2006; 21(7):1131-4. DOI: 10.1007/s00464-006-9062-2. View

Fang W, Chen W, Chen Y, Jiang Y . Selective three-field lymphadenectomy for thoracic esophageal squamous carcinoma. Dis Esophagus. 2007; 20(3):206-11. DOI: 10.1111/j.1442-2050.2007.00671.x. View

Yasuda S, Shimada H, Chino O, Tanaka H, Kenmochi T, Takechi M . Sentinel lymph node detection with Tc-99m tin colloids in patients with esophagogastric cancer. Jpn J Clin Oncol. 2003; 33(2):68-72. DOI: 10.1093/jjco/hyg020. View

Hur H, Jeon H, Kim W . Laparoscopy-assisted distal gastrectomy with D2 lymphadenectomy for T2b advanced gastric cancers: three years' experience. J Surg Oncol. 2008; 98(7):515-9. DOI: 10.1002/jso.21155. View

Takeuchi H, Fujii H, Ando N, Ozawa S, Saikawa Y, Suda K . Validation study of radio-guided sentinel lymph node navigation in esophageal cancer. Ann Surg. 2009; 249(5):757-63. DOI: 10.1097/SLA.0b013e3181a38e89. View

Kitagawa Y, Fujii H, Mukai M, Kubota T, Ando N, Watanabe M . The role of the sentinel lymph node in gastrointestinal cancer. Surg Clin North Am. 2001; 80(6):1799-809. DOI: 10.1016/s0039-6109(05)70262-0. View

Akiyama H, Tsurumaru M, Udagawa H, Kajiyama Y . Radical lymph node dissection for cancer of the thoracic esophagus. Ann Surg. 1994; 220(3):364-72; discussion 372-3. PMC: 1234394. DOI: 10.1097/00000658-199409000-00012. View

10.

Wang Z, Dong Z, Chen J, Liu J . Diagnostic value of sentinel lymph node biopsy in gastric cancer: a meta-analysis. Ann Surg Oncol. 2011; 19(5):1541-50. DOI: 10.1245/s10434-011-2124-2. View

11.

Goto O, Takeuchi H, Kawakubo H, Matsuda S, Kato F, Sasaki M . Feasibility of non-exposed endoscopic wall-inversion surgery with sentinel node basin dissection as a new surgical method for early gastric cancer: a porcine survival study. Gastric Cancer. 2014; 18(2):440-5. DOI: 10.1007/s10120-014-0358-y. View

12.

Matsuda T, Takeuchi H, Tsuwano S, Nakahara T, Mukai M, Kitagawa Y . Sentinel node mapping in adenocarcinoma of the esophagogastric junction. World J Surg. 2014; 38(9):2337-44. DOI: 10.1007/s00268-014-2573-4. View

13.

Grotenhuis B, Wijnhoven B, van Marion R, van Dekken H, Hop W, Tilanus H . The sentinel node concept in adenocarcinomas of the distal esophagus and gastroesophageal junction. J Thorac Cardiovasc Surg. 2009; 138(3):608-12. DOI: 10.1016/j.jtcvs.2008.11.061. View

14.

Thompson S, Bartholomeusz D, Devitt P, Lamb P, Ruszkiewicz A, Jamieson G . Feasibility study of sentinel lymph node biopsy in esophageal cancer with conservative lymphadenectomy. Surg Endosc. 2010; 25(3):817-25. DOI: 10.1007/s00464-010-1265-x. View

15.

Morton D, Wen D, Wong J, Economou J, Cagle L, Storm F . Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 1992; 127(4):392-9. DOI: 10.1001/archsurg.1992.01420040034005. View

16.

Tajima Y, Murakami M, Yamazaki K, Masuda Y, Kato M, Sato A . Sentinel node mapping guided by indocyanine green fluorescence imaging during laparoscopic surgery in gastric cancer. Ann Surg Oncol. 2010; 17(7):1787-93. DOI: 10.1245/s10434-010-0944-0. View

17.

Kim Y, Baik Y, Yun Y, Nam B, Kim D, Choi I . Improved quality of life outcomes after laparoscopy-assisted distal gastrectomy for early gastric cancer: results of a prospective randomized clinical trial. Ann Surg. 2008; 248(5):721-7. DOI: 10.1097/SLA.0b013e318185e62e. View

18.

Takeuchi H, Goto O, Yahagi N, Kitagawa Y . Function-preserving gastrectomy based on the sentinel node concept in early gastric cancer. Gastric Cancer. 2016; 20(Suppl 1):53-59. DOI: 10.1007/s10120-016-0649-6. View

19.

Mayanagi S, Takeuchi H, Kamiya S, Niihara M, Nakamura R, Takahashi T . Suitability of sentinel node mapping as an index of metastasis in early gastric cancer following endoscopic resection. Ann Surg Oncol. 2014; 21(9):2987-93. DOI: 10.1245/s10434-014-3662-1. View

20.

Takeuchi H, Kawakubo H, Nakamura R, Fukuda K, Takahashi T, Wada N . Clinical Significance of Sentinel Node Positivity in Patients with Superficial Esophageal Cancer. World J Surg. 2015; 39(12):2941-7. DOI: 10.1007/s00268-015-3217-z. View