Hepatitis B Virus Infection: Defective Surface Antigen Expression and Pathogenesis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2018 Aug 23

PMID 30131655

Citations 20

Authors

Chun-Chen Wu

Ying-Shan Chen

Liang Cao

Xin-Wen Chen

Meng-Ji Lu

Affiliations

Soon will be listed here.

Abstract

Hepatitis B virus (HBV) infection is a global public health concern. HBV causes chronic infection in patients and can lead to liver cirrhosis, hepatocellular carcinoma, and other severe liver diseases. Thus, understanding HBV-related pathogenesis is of particular importance for prevention and clinical intervention. HBV surface antigens are indispensable for HBV virion formation and are useful viral markers for diagnosis and clinical assessment. During chronic HBV infection, HBV genomes may acquire and accumulate mutations and deletions, leading to the expression of defective HBV surface antigens. These defective HBV surface antigens have been found to play important roles in the progression of HBV-associated liver diseases. In this review, we focus our discussion on the nature of defective HBV surface antigen mutations and their contribution to the pathogenesis of fulminant hepatitis B. The relationship between defective surface antigens and occult HBV infection are also discussed.

Citing Articles

Occult Hepatitis B Virus Infection in Hepatic Diseases and Its Significance for the WHO's Elimination Plan of Viral Hepatitis.

Bucio-Ortiz L, Enriquez-Navarro K, Maldonado-Rodriguez A, Torres-Flores J, Cevallos A, Salcedo M Pathogens. 2024; 13(8).

PMID: 39204261 PMC: 11357063. DOI: 10.3390/pathogens13080662.

Hepatitis B Surface Antigen Isoforms: Their Clinical Implications, Utilisation in Diagnosis, Prevention and New Antiviral Strategies.

Lazarevic I, Banko A, Miljanovic D, Cupic M Pathogens. 2024; 13(1).

PMID: 38251353 PMC: 10818932. DOI: 10.3390/pathogens13010046.

Interconnection of cellular autophagy and endosomal vesicle trafficking and its role in hepatitis B virus replication and release.

Li J, Lin Y, Wang X, Lu M Virol Sin. 2024; 39(1):24-30.

PMID: 38211880 PMC: 10877419. DOI: 10.1016/j.virs.2024.01.001.

CD8 T cell-mediated depletion of HBV surface-antigen-expressing, bilineal-differentiated liver carcinoma cells generates highly aggressive escape variants.

Qiu N, Srikanth A, Mulaw M, Tharehalli U, Selvachandran S, Wagner M Oncoimmunology. 2023; 12(1):2215096.

PMID: 37261086 PMC: 10228399. DOI: 10.1080/2162402X.2023.2215096.

Scratching the Surface Takes a Toll: Immune Recognition of Viral Proteins by Surface Toll-like Receptors.

Hatton A, Guerra F Viruses. 2023; 15(1).

PMID: 36680092 PMC: 9863796. DOI: 10.3390/v15010052.

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