Role of Nuclear Factor κB in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Overview

Journal Neural Regen Res

Date 2018 Aug 22

PMID 30127103

Citations 35

Authors

Yuan Yue

Sarrabeth Stone

Wensheng Lin

Affiliations

Soon will be listed here.

Abstract

The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the central nervous system (CNS). It has been shown that NF-κB is activated in multiple cell types in the CNS of MS patients, including T cells, microglia/macrophages, astrocytes, oligodendrocytes, and neurons. Interestingly, data from animal model studies, particularly studies of experimental autoimmune encephalomyelitis, have suggested that NF-κB activation in these individual cell types has distinct effects on the development of MS. In this review, we will cover the current literature on NF-κB and the evidence for its role in the development of MS and its animal model experimental autoimmune encephalomyelitis.

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