Increased Expression of Pendrin in Eosinophilic Chronic Rhinosinusitis with Nasal Polyps

Overview

Journal Braz J Otorhinolaryngol

Specialty Otorhinolaryngology

Date 2018 Aug 22

PMID 30126769

Citations 6

Authors

Taku Ito

Satoshi Ikeda

Tomoaki Asamori

Keiji Honda

Yoshiyuki Kawashima

Ken Kitamura

Keiko Suzuki

Takeshi Tsutsumi

Affiliations

Soon will be listed here.

Abstract

Introduction: Chronic rhinosinusitis with nasal polyps is a heterogeneous disease and appropriate diagnostic algorithms in individual cases are necessary for effective medical treatment.

Objective: The purpose of this study was to clarify the relationship between the pendrin expression of nasal polyps and clinical and pathological characteristic features of eosinophilic chronic rhinosinusitis.

Methods: A total of 68 patients were classified into eosinophilic chronic rhinosinusitis or non-eosinophilic chronic rhinosinusitis groups according to the degree of eosinophilic infiltration into the nasal polyps. Clinical, hematological, and immunohistochemical analyses were performed and statistically compared between both groups.

Results: Thirty-eight were classified into eosinophilic chronic rhinosinusitis and 30 into non-eosinophilic chronic rhinosinusitis groups. There were no significant differences in age distribution, sex ratio, prevalence of asthma, or any other complications between the groups. The mean Lund-Mackay score and the number of serum eosinophils was significantly higher in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. The pendrin expression was more frequently detected in the epithelial surface layer of nasal polyps in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis groups. In addition, mucin 5AC was more widely expressed in the eosinophilic chronic rhinosinusitis than in the non-eosinophilic chronic rhinosinusitis.

Conclusion: Increased expression of pendrin and mucin 5AC in the nasal polyps would be associated with development of eosinophilic chronic rhinosinusitis. This finding could allow the development of a novel therapeutic agent targeted specifically to patients with eosinophilic chronic rhinosinusitis.

Citing Articles

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Immunological Aspects of Chronic Rhinosinusitis.

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Clinical and Laboratory Features of Various Criteria of Eosinophilic Chronic Rhinosinusitis: A Systematic Review and Meta-Analysis.

Kim D, Kim S, Basurrah M, Hwang S Clin Exp Otorhinolaryngol. 2022; 15(3):230-246.

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References

Ishida A, Ohta N, Suzuki Y, Kakehata S, Okubo K, Ikeda H . Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis. Allergol Int. 2012; 61(4):589-95. DOI: 10.2332/allergolint.11-OA-0370. View

Fokkens W, Lund V, Mullol J, Bachert C, Alobid I, Baroody F . European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012; 23. View

Ono N, Kusunoki T, Ikeda K . Relationships between IL-17A and macrophages or MUC5AC in eosinophilic chronic rhinosinusitis and proposed pathological significance. Allergy Rhinol (Providence). 2013; 3(2):e50-4. PMC: 3548608. DOI: 10.2500/ar.2012.3.0030. View

Makihara S, Okano M, Fujiwara T, Kariya S, Noda Y, Higaki T . Regulation and characterization of IL-17A expression in patients with chronic rhinosinusitis and its relationship with eosinophilic inflammation. J Allergy Clin Immunol. 2010; 126(2):397-400, 400.e1-11. DOI: 10.1016/j.jaci.2010.05.014. View

Van Crombruggen K, Zhang N, Gevaert P, Tomassen P, Bachert C . Pathogenesis of chronic rhinosinusitis: inflammation. J Allergy Clin Immunol. 2011; 128(4):728-32. DOI: 10.1016/j.jaci.2011.07.049. View

Nakagami Y, Favoreto Jr S, Zhen G, Park S, Nguyenvu L, Kuperman D . The epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma model. J Immunol. 2008; 181(3):2203-10. PMC: 2491716. DOI: 10.4049/jimmunol.181.3.2203. View

Bizhanova A, Kopp P . Controversies concerning the role of pendrin as an apical iodide transporter in thyroid follicular cells. Cell Physiol Biochem. 2011; 28(3):485-90. DOI: 10.1159/000335103. View

Nofziger C, Dossena S, Suzuki S, Izuhara K, Paulmichl M . Pendrin function in airway epithelia. Cell Physiol Biochem. 2011; 28(3):571-8. DOI: 10.1159/000335115. View

Otto B, Wenzel S . The role of cytokines in chronic rhinosinusitis with nasal polyps. Curr Opin Otolaryngol Head Neck Surg. 2008; 16(3):270-4. DOI: 10.1097/MOO.0b013e3282fb2885. View

10.

Royaux I, Wall S, Karniski L, Everett L, Suzuki K, Knepper M . Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A. 2001; 98(7):4221-6. PMC: 31206. DOI: 10.1073/pnas.071516798. View

11.

Baba S, Kagoya R, Kondo K, Suzukawa M, Ohta K, Yamasoba T . T-cell phenotypes in chronic rhinosinusitis with nasal polyps in Japanese patients. Allergy Asthma Clin Immunol. 2015; 11:33. PMC: 4653844. DOI: 10.1186/s13223-015-0100-2. View

12.

Nakao I, Kanaji S, Ohta S, Matsushita H, Arima K, Yuyama N . Identification of pendrin as a common mediator for mucus production in bronchial asthma and chronic obstructive pulmonary disease. J Immunol. 2008; 180(9):6262-9. DOI: 10.4049/jimmunol.180.9.6262. View

13.

Seshadri S, Lu X, Purkey M, Homma T, Choi A, Carter R . Increased expression of the epithelial anion transporter pendrin/SLC26A4 in nasal polyps of patients with chronic rhinosinusitis. J Allergy Clin Immunol. 2015; 136(6):1548-1558.e7. PMC: 4679496. DOI: 10.1016/j.jaci.2015.05.024. View

14.

Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H . Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study. Allergy. 2015; 70(8):995-1003. PMC: 5032997. DOI: 10.1111/all.12644. View

15.

Madeo A, Manichaikul A, Pryor S, Griffith A . Do mutations of the Pendred syndrome gene, SLC26A4, confer resistance to asthma and hypertension?. J Med Genet. 2009; 46(6):405-6. PMC: 3403713. DOI: 10.1136/jmg.2008.063610. View

16.

Ito T, Choi B, King K, Zalewski C, Muskett J, Chattaraj P . SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct. Cell Physiol Biochem. 2011; 28(3):545-52. PMC: 3709178. DOI: 10.1159/000335119. View

17.

Scanlon K, Gau Y, Zhu J, Skerry C, Wall S, Soleimani M . Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection. Infect Immun. 2014; 82(10):4212-21. PMC: 4187853. DOI: 10.1128/IAI.02222-14. View

18.

Lund V, Kennedy D . Staging for rhinosinusitis. Otolaryngol Head Neck Surg. 1997; 117(3 Pt 2):S35-40. DOI: 10.1016/S0194-59989770005-6. View

19.

Rozenfeld J, Efrati E, Adler L, Tal O, Carrithers S, Alper S . Transcriptional regulation of the pendrin gene. Cell Physiol Biochem. 2011; 28(3):385-96. PMC: 3709172. DOI: 10.1159/000335100. View

20.

Nofziger C, Vezzoli V, Dossena S, Schonherr T, Studnicka J, Nofziger J . STAT6 links IL-4/IL-13 stimulation with pendrin expression in asthma and chronic obstructive pulmonary disease. Clin Pharmacol Ther. 2011; 90(3):399-405. DOI: 10.1038/clpt.2011.128. View