Aluminium in Brain Tissue in Multiple Sclerosis

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2018 Aug 22

PMID 30126209

Citations 14

Authors

Matthew Mold

Agata Chmielecka

Maria Raquel Ramirez Rodriguez

Femia Thom

Caroline Linhart

Andrew King

Christopher Exley

Affiliations

Soon will be listed here.

Abstract

Multiple sclerosis (MS) is a devastating and debilitating neurodegenerative disease of unknown cause. A consensus suggests the involvement of both genetic and environmental factors of which the latter may involve human exposure to aluminium. There are no data on the content and distribution of aluminium in human brain tissue in MS. The aluminium content of brain tissue from 14 donors with a diagnosis of MS was determined by transversely heated graphite furnace atomic absorption spectrometry. The location of aluminium in the brain tissue of two donors was investigated by aluminium-specific fluorescence microscopy. The aluminium content of brain tissue in MS was universally high with many tissues bearing concentrations in excess of 10 μg/g dry wt. (10 ppm) and some exceeding 50 ppm. There were no statistically significant relationships between brain lobes, donor age or donor gender. Aluminium-specific fluorescence successfully identified aluminium in brain tissue in both intracellular and extracellular locations. The association of aluminium with corpora amylacea suggests a role for aluminium in neurodegeneration in MS.

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References

Exley C . Human exposure to aluminium. Environ Sci Process Impacts. 2013; 15(10):1807-1816. DOI: 10.1039/c3em00374d. View

Exley C, Vickers T . Elevated brain aluminium and early onset Alzheimer's disease in an individual occupationally exposed to aluminium: a case report. J Med Case Rep. 2014; 8:41. PMC: 3923550. DOI: 10.1186/1752-1947-8-41. View

Selmaj K, Pawlowska Z, Walczak A, Koziolkiewicz W, Raine C, Cierniewski C . Corpora amylacea from multiple sclerosis brain tissue consists of aggregated neuronal cells. Acta Biochim Pol. 2008; 55(1):43-9. View

Exley C, Mamutse G, Korchazhkina O, Pye E, Strekopytov S, Polwart A . Elevated urinary excretion of aluminium and iron in multiple sclerosis. Mult Scler. 2006; 12(5):533-40. DOI: 10.1177/1352458506071323. View

Montalban X, Hauser S, Kappos L, Arnold D, Bar-Or A, Comi G . Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis. N Engl J Med. 2016; 376(3):209-220. DOI: 10.1056/NEJMoa1606468. View

Mirza A, King A, Troakes C, Exley C . Aluminium in brain tissue in familial Alzheimer's disease. J Trace Elem Med Biol. 2017; 40:30-36. DOI: 10.1016/j.jtemb.2016.12.001. View

Lublin F, Reingold S, Cohen J, Cutter G, Soelberg Sorensen P, Thompson A . Defining the clinical course of multiple sclerosis: the 2013 revisions. Neurology. 2014; 83(3):278-86. PMC: 4117366. DOI: 10.1212/WNL.0000000000000560. View

Thompson A . Challenge of progressive multiple sclerosis therapy. Curr Opin Neurol. 2017; 30(3):237-240. DOI: 10.1097/WCO.0000000000000453. View

Jones K, Linhart C, Hawkins C, Exley C . Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis. EBioMedicine. 2017; 26:60-67. PMC: 5832610. DOI: 10.1016/j.ebiom.2017.10.028. View

10.

Verstraeten S, Golub M, Keen C, Oteiza P . Myelin is a preferential target of aluminum-mediated oxidative damage. Arch Biochem Biophys. 1997; 344(2):289-94. DOI: 10.1006/abbi.1997.0146. View

11.

Golub M, Tarara R . Morphometric studies of myelination in the spinal cord of mice exposed developmentally to aluminum. Neurotoxicology. 2000; 20(6):953-9. View

12.

Auge E, Cabezon I, Pelegri C, Vilaplana J . New perspectives on corpora amylacea in the human brain. Sci Rep. 2017; 7:41807. PMC: 5290524. DOI: 10.1038/srep41807. View

13.

House E, Esiri M, Forster G, Ince P, Exley C . Aluminium, iron and copper in human brain tissues donated to the Medical Research Council's Cognitive Function and Ageing Study. Metallomics. 2011; 4(1):56-65. DOI: 10.1039/c1mt00139f. View

14.

Exley C, Esiri M . Severe cerebral congophilic angiopathy coincident with increased brain aluminium in a resident of Camelford, Cornwall, UK. J Neurol Neurosurg Psychiatry. 2006; 77(7):877-9. PMC: 2117501. DOI: 10.1136/jnnp.2005.086553. View

15.

Ontaneda D, Thompson A, Fox R, Cohen J . Progressive multiple sclerosis: prospects for disease therapy, repair, and restoration of function. Lancet. 2016; 389(10076):1357-1366. DOI: 10.1016/S0140-6736(16)31320-4. View

16.

Mold M, Eriksson H, Siesjo P, Darabi A, Shardlow E, Exley C . Unequivocal identification of intracellular aluminium adjuvant in a monocytic THP-1 cell line. Sci Rep. 2014; 4:6287. PMC: 4155332. DOI: 10.1038/srep06287. View

17.

Mold M, Umar D, King A, Exley C . Aluminium in brain tissue in autism. J Trace Elem Med Biol. 2018; 46:76-82. DOI: 10.1016/j.jtemb.2017.11.012. View

18.

Mirza A, King A, Troakes C, Exley C . The Identification of Aluminum in Human Brain Tissue Using Lumogallion and Fluorescence Microscopy. J Alzheimers Dis. 2016; 54(4):1333-1338. PMC: 5088403. DOI: 10.3233/JAD-160648. View