Cognitive and Neural Facets of Dissociation in a Traumatized Population

Overview

Journal Emotion

Publisher American Psychological Association

Specialty Psychology

Date 2018 Aug 21

PMID 30124316

Citations 9

Authors

Negar Fani

Tricia Z King

Abigail Powers

Raven A Hardy

Greg J Siegle

Robert J Blair

Sindhuja Surapaneni

Sanne van Rooij

Kerry J Ressler

Tanja Jovanovic

Bekh Bradley

Affiliations

Soon will be listed here.

Abstract

Dissociative phenomena are frequently experienced by psychologically traumatized people. However, little is known about the cognitive profiles of highly dissociative traumatized individuals, and corresponding patterns of neural connectivity when attentional networks are engaged in the context of emotion. One hundred seventeen traumatized women completed the multiscale dissociation inventory (MDI) and neuropsychological testing; MDI scores were used to classify high- and low-dissociative participants. Forty-six participants also underwent fMRI during performance of an attentional control task that incorporates emotionally distracting images (Affective Number Stroop; ANS). Compared to low-dissociative participants, high-dissociative participants demonstrated better performance on an executive functioning task (F1,111 = 4.64, p = .03), worse performance on a task of visual memory (F1,111 = 9.52, p = .003), and similar performance on all other neuropsychological measures. In addition, dissociative symptoms were negatively correlated with functional connectivity between the amygdala and right anterior insula in response to trauma-related ANS trials. These findings indicate that highly dissociative traumatized people experience difficulties with attentional control in the context of emotionally evocative stimuli, but in a neutral context, their overall cognitive profiles are similar to low-dissociative people. Highly dissociative participants also demonstrated weaker connectivity between the amygdala and insula in response to trauma-relevant images. Evocative, trauma-relevant stimuli appear to disrupt neutral networks involved with attention to salient cues and interoception in highly dissociative traumatized individuals. (PsycINFO Database Record (c) 2019 APA, all rights reserved).

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References

Kurtz M, Ragland J, Bilker W, Gur R, Gur R . Comparison of the continuous performance test with and without working memory demands in healthy controls and patients with schizophrenia. Schizophr Res. 2001; 48(2-3):307-16. DOI: 10.1016/s0920-9964(00)00060-8. View

Kurtz M, Ragland J, Moberg P, Gur R . The Penn Conditional Exclusion Test: a new measure of executive-function with alternate forms of repeat administration. Arch Clin Neuropsychol. 2004; 19(2):191-201. DOI: 10.1016/S0887-6177(03)00003-9. View

Sachs G, Steger-Wuchse D, Kryspin-Exner I, Gur R, Katschnig H . Facial recognition deficits and cognition in schizophrenia. Schizophr Res. 2004; 68(1):27-35. DOI: 10.1016/S0920-9964(03)00131-2. View

DePrince A, Freyd J . Forgetting trauma stimuli. Psychol Sci. 2004; 15(7):488-92. DOI: 10.1111/j.0956-7976.2004.00706.x. View

de Ruiter M, Phaf R, Elzinga B, van Dyck R . Dissociative style and individual differences in verbal working memory span. Conscious Cogn. 2004; 13(4):821-8. DOI: 10.1016/j.concog.2004.08.002. View

Veltman D, de Ruiter M, Rombouts S, Lazeron R, Barkhof F, van Dyck R . Neurophysiological correlates of increased verbal working memory in high-dissociative participants: a functional MRI study. Psychol Med. 2005; 35(2):175-85. DOI: 10.1017/s0033291704002971. View

Briere J, Weathers F, Runtz M . Is dissociation a multidimensional construct? Data from the Multiscale Dissociation Inventory. J Trauma Stress. 2005; 18(3):221-31. DOI: 10.1002/jts.20024. View

Briere J . Dissociative symptoms and trauma exposure: specificity, affect dysregulation, and posttraumatic stress. J Nerv Ment Dis. 2006; 194(2):78-82. DOI: 10.1097/01.nmd.0000198139.47371.54. View

Roca V, Hart J, Kimbrell T, Freeman T . Cognitive function and dissociative disorder status among veteran subjects with chronic posttraumatic stress disorder: a preliminary study. J Neuropsychiatry Clin Neurosci. 2006; 18(2):226-30. DOI: 10.1176/jnp.2006.18.2.226. View

10.

Morgan 3rd C, Doran A, Steffian G, Hazlett G, Southwick S . Stress-induced deficits in working memory and visuo-constructive abilities in Special Operations soldiers. Biol Psychiatry. 2006; 60(7):722-9. DOI: 10.1016/j.biopsych.2006.04.021. View

11.

Mula M, Pini S, Cassano G . The neurobiology and clinical significance of depersonalization in mood and anxiety disorders: a critical reappraisal. J Affect Disord. 2006; 99(1-3):91-9. DOI: 10.1016/j.jad.2006.08.025. View

12.

Elzinga B, Ardon A, Heijnis M, de Ruiter M, van Dyck R, Veltman D . Neural correlates of enhanced working-memory performance in dissociative disorder: a functional MRI study. Psychol Med. 2006; 37(2):235-45. DOI: 10.1017/S0033291706008932. View

13.

Cromer L, Stevens C, DePrince A, Pears K . The relationship between executive attention and dissociation in children. J Trauma Dissociation. 2006; 7(4):135-53. DOI: 10.1300/J229v07n04_08. View

14.

Blair K, Smith B, Mitchell D, Morton J, Vythilingam M, Pessoa L . Modulation of emotion by cognition and cognition by emotion. Neuroimage. 2007; 35(1):430-40. PMC: 1862681. DOI: 10.1016/j.neuroimage.2006.11.048. View

15.

Hoistad M, Barbas H . Sequence of information processing for emotions through pathways linking temporal and insular cortices with the amygdala. Neuroimage. 2008; 40(3):1016-33. PMC: 2680198. DOI: 10.1016/j.neuroimage.2007.12.043. View

16.

Lysaker P, LaRocco V . The prevalence and correlates of trauma-related symptoms in schizophrenia spectrum disorder. Compr Psychiatry. 2008; 49(4):330-4. DOI: 10.1016/j.comppsych.2007.12.003. View

17.

Bob P, Fedor-Freybergh P, Jasova D, Bizik G, Susta M, Pavlat J . Dissociative symptoms and neuroendocrine dysregulation in depression. Med Sci Monit. 2008; 14(10):CR499-504. View

18.

DePrince A, Weinzierl K, Combs M . Stroop performance, dissociation, and trauma exposure in a community sample of children. J Trauma Dissociation. 2008; 9(2):209-23. DOI: 10.1080/15299730802048603. View

19.

Gillespie C, Bradley B, Mercer K, Smith A, Conneely K, Gapen M . Trauma exposure and stress-related disorders in inner city primary care patients. Gen Hosp Psychiatry. 2009; 31(6):505-14. PMC: 2785858. DOI: 10.1016/j.genhosppsych.2009.05.003. View

20.

Gur R, Richard J, Hughett P, Calkins M, Macy L, Bilker W . A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validation. J Neurosci Methods. 2009; 187(2):254-62. PMC: 2832711. DOI: 10.1016/j.jneumeth.2009.11.017. View