Animal Tests for Anxiety-like and Depression-like Behavior in Rats

Overview

Journal Interdiscip Toxicol

Specialty Biology

Date 2018 Aug 21

PMID 30123035

Citations 81

Authors

Kristina Belovicova

Eszter Bogi

Kristina Csatlosova

Michal Dubovicky

Affiliations

Soon will be listed here.

Abstract

An animal model of human behavior represents a complex of cognitive and/or emotional processess, which are translated from animals to humans. A behavioral test is developed primarily and specifically to verify and support a theory of cognition or emotion; it can also be used to verify a theory of a psychopathology, but it is not developed for a particular type of psychopathology. The paper reviews tests commonly used in novel drug discovery research. Focus is especially on tests which can evaluate anxiety-like (openfield test, novelty suppressed feeding, elevated plus maze, light/dark box, stressinduced hyperthermia) and depression-like behaviors (forced swim test, tail suspension test, sucrose preference test) as they represent an important methodological tool in pre-clinical as well as in behavioral toxicology studies.

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